Painful diabetic neuropathy is a common complication of diabetes mellitus which is poorly controlled by conventional analgesics. This study investigates if treatment with an heme oxygenase 1 (HO-1) inducer, cobalt protoporphyrin IX (CoPP), could modulate the allodynia and hyperalgesia induced by diabetes and enhanced the antinociceptive effects of morphine. In a diabetic mice model induced by t...

What is the diabetic patient’s experience of pain with regards to diabetic foot ulcers, and why is this important to clinicians? These questions were answered, and important issues raised, at the Diabetic Foot Study Group’s 10th Scientific Meeting, held between 28–30 September 2012 in Berlin-Potsdam, Germany. Stimulating presentations were delivered by Dr Clifford Richardson of the University o...

Thirty-nine patients with painful diabetic peripheral neuropathy were selected for a follow-up study to determine the natural history of this condition. Symptoms, motor conduction velocities (MCV) and ankle pressure indices were recorded at the initial assessment and after a mean study period of 4.7 years. Thirty-six patients completed the study and showed no significant changes in symptoms, bu...

Diabetic neuropathy is a nerve disorder manifested by different faceted condition affecting up to half of individuals with persistent diabetes. Symptoms associated this disease such as palsy, painful polyneuropathy, thoracoabdominal neuropathy, autonomic diabetic amyotrophy, mononeuropathy multiplex, caused motor, sensory, and dysfunction which affects peripheral nervous system, gastrointestina...

Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may model aspects of painful diabetic neuropathy. This study examined the contribution of spinal prostaglandin production to this exaggerated hyperalgesic behavior. Rats were implanted with spinal dialysis probes and received noxious stimulation to the hind paw by subcutaneous injection of 0.5% formalin ...

INTRODUCTION Diabetes beyond the well described diabetic retinopathy symptoms leads also to other ophthalmology problems. Among them, there are less known neuropathies and other neuroophthalmological disorders. To determine whether optic neuropathy coexists with painful peripheral neuropathy. MATERIALS AND METHODS 50 patients (99 eyes) with diabetes (type one 21 patients and type two 29 patie...

Insulin dependent diabetes mellitus (IDDM) is associated with several complications including painful diabetic neuropathy. Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. Furthermore, it has been suggested that glucose may be an important mediating factor in these painful symptoms. In the present study, pain threshold was assess...