Hanatoxin 1 (HaTx1) is a polypeptide toxin isolated from spider venoms. HaTx1 inhibits the voltage-gated potassium channel kv2.1 potently with nanomolar affinities. Its receptor site has been shown to contain the S3b-S4a paddle of the voltage sensor (VS). Here, the binding of HaTx1 to the VSs of human Kv2.1 in the open and resting states are examined using a molecular docking method and molecul...

The plasma concentration of indomethacin was measured after the rectal administration of water-soluble and fatty base suppositories in rats. The results were compared with the in vitro indomethacin release from suppositories determined by Paddle method using three different types of membranes: cellulose membrane, artificial sausage membrane and natural sausage membrane. The plasma concentration...

Piroxicam has two different crystalline forms (known as needle and cubic forms), that they are different in physicochemical properties such as biological solubility. In the current research, using Taguchi experimental design approach the influences of five operating variables on formation of the piroxicam polymorph shapes in recrystallization were studied. The variables include type of solvent,...

A new binuclear paddle-wheel palladium(II) complex of [Pd2(μ-mtzt)4]dmgH2 (1) has been prepared by the treatment of PdCl2 in acetonitrile with mixture of 1-methyl-1H-1,2,3,4-tetrazole-5-thiol (Hmtzt) and dimethylglyoxime (dmgH2) in methanol. Resulted complex was characterized by elemental analysis (CHNS), IR, UV–Vis absorption, 1H NMR spectroscopy and its structure was determined with single-cr...

To improve the understanding of mixing performance double shaft, batch-type paddle mixers, discrete element method (DEM) in combination with a Plackett–Burman design experiments simulation plan is used to identify factor significance on system’s performance. Effects several factors, including three material properties (particle size, particle density and composition), operational conditions (in...

A self-assembled M(2)L(4) palladium-pyridyl cluster with a "paddle-wheel" structure shows binding affinity in competitive organic solvents for neutral organic guests that possess both the correct size and electrostatic complementarity.

BACKGROUND The fibula free flap is a reliable method for reconstructing composite head and neck defects. However, its skin paddle has drawbacks, including its thickness, hair-bearing surface, desquamation, difficulty insetting it into maxillary defects, and the potential need for skin-grafting the donor site. The fibula osteo-adipofascial flap (FOAFF) is a modification of the fibula flap that o...

Hands-on experiments for upper-level engineering courses greatly enhance student enthusiasm, core-concept comprehension and retention. Given the high cost of commercial instructional control systems lab equipment, we sought to provide an affordable, robust solution to hands-on learning, without compromising technical caliber. To this end, we have developed a low-cost dynamic plant and data acqu...