نتایج جستجو برای: pachyonychia congenita
تعداد نتایج: 3662 فیلتر نتایج به سال:
Molecular characterization and assessment of therapeutic outcomes for inherited cutaneous disorders requires faithful preclinical models. In this study we report the establishment of two different skin-humanized pachyonychia congenita (PC) model systems, based on permanent engraftment of bioengineered skin equivalents generated from patient skin cells onto immunodeficient mice. Using keratinocy...
Palmoplantar keratoderma (PPK) are debilitating lesions that arise in individuals with pachyonychia congenita (PC) and feature upregulation of danger-associated molecular patterns and skin barrier regulators. The defining features of PC-associated PPK are reproduced in mice null for keratin 16 (Krt16), which is commonly mutated in PC patients. Here, we have shown that PPK onset is preceded by o...
Pc3 geomagnetic ®eld ̄uctuations detected at low latitude (L'Aquila, Italy) during the passage of a high velocity solar wind stream, characterized by variable interplanetary magnetic ®eld conditions, are analyzed. Higher frequency resonant ̄uctuations and lower frequency phenomena are simultaneously observed; the intermittent appearance and the variable frequency of the longer period modes can ...
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