High-risk human papillomaviruses (HPVs) infect stratified epithelia to establish persistent infections that maintain low-copy-number episomes in infected basal cells. Amplification of viral genomes occurs upon keratinocyte differentiation, followed by virion synthesis. During persistent HPV infections, viral proteins act to evade surveillance by both innate and adaptive immune responses. One of...

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Preconditioning (PC) protects against ischemia-reperfusion (I/R) injury via the activation of the JAK-STAT pathway. We hypothesized that the mediators responsible for PC can be transferred to naive myocardium through the coronary effluent. Langendorff-perfused hearts from male Sprague-Dawley rats were randomized to paired donor/acceptor protocols with or without PC in the presence or absence of...

The human inducible nitric oxide synthase (hiNOS) gene is expressed in several disease states and is also important in the normal immune response. Previously, we described a cytokine-responsive enhancer between -5.2 and -6.1 kb in the 5'-flanking hiNOS promoter DNA, which contains multiple nuclear factor kappa beta (NF-kappa B) elements. Here, we describe the role of the IFN-Jak kinase-Stat (si...

We studied the effect of leukotriene D(4) (LTD(4)) on a human bronchial epithelial cell line (16HBE) overexpressing the cysteinyl leukotriene (CysLT) (1) receptor (HBECysLT(1)R), looking at the associated signal transduction mechanisms as well as at effects on inflammatory cell adhesion. The results obtained showed that LTD(4) increases the phosphorylation of extracellular signal-regulated prot...

We present a calculation of the pion quark momentum fraction, $?x?$, and its third Mellin moment $?{x}^{2}?$. also obtain directly, for first time, $?x?$ $?{x}^{2}?$ kaon using local operators. use an ensemble two degenerate light, strange, charm (${N}_{f}=2+1+1$) maximally twisted mass fermions with clover improvement. The masses are chosen so that they reproduce about 260 MeV 530 MeV. lattice...

OBJECTIVES The goal of this study was to evaluate the impact of the STAT-MI (ST-Segment Analysis Using Wireless Technology in Acute Myocardial Infarction) network on outcomes in the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). BACKGROUND Shortening door-to-balloon (D2B) time remains a national priority for the treatment of STEMI. We previously repo...

The genus Psyra Walker, 1860 in China is reviewed. Thirteen species are recognized, of which, P. breviprotrusa sp. nov. is described as new to science, and P. moderata Inoue, 1982, P. gracilis Yazaki, 1992 and P. boarmiata (Graeser, 1892) are recorded for the first time from China. P. cuneata szetschwana Wehrli, 1953 and P. cuneata dsagara Wehrli, 1953 are upgraded to specific level, i.e. P. sz...

J. T. Devreese, E. P. Pokatilov, V. M. Fomin, V. N. Gladilin Theoretische Fysica van de Vaste Stof, Universiteit Antwerpen (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium Universiteit Antwerpen (RUCA), Groenenborgerlaan 171, B-2020 Antwerpen, Belgium TU Eindhoven, P. O. Box 513, 5600 MB Eindhoven, The Netherlands Fizica Structurilor Multistratificate, Universitatea de Stat din Moldova, s...