objective (s): from a genetic point of view, epilepsy is a polygenic multifactorial syndrome. the scn1a and b genes belong to a family of genes that provide instructions for making sodium channels. understanding the relevance of scn1a and scn1b gene polymorphisms to plasma concentration of carbamazepine (cbz) and its active metabolite carbamazepine 10, 11 epoxide (cbze), may shed more light on ...

background: this study aimed to evaluate the role of efflux pump regulator and oxa-23 genes in imipenem resistance acinetobacter baumannii strains isolated from hospitalized patients in tehran, iran. methods: this study was conducted on 60 a. baumannii isolates collected from patients admitted to the shahid motahari and taleghani hospitals in tehran during 2013-14. antibiotic susceptibility tes...

the one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1h-pyrazol-5-ols) by tandem knoevenagel-michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded n-propylpiperazine sulfamic acid (sbppsa) as a recyclable solid acid catalyst was reported. sbppsa showed much the same efficiency when used in consecutive reaction runs.

introduction air pollution is one of the critical challenges in metropolitans around the world. according to world health organization (who), three millions people die from air pollution annually. in some studies mortality costs by air pollution was estimated. social cost of air pollution was estimated 28990 billions rials in tehran city. the mortality cost by air pollution was estimated about ...

paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, in this study, paraquat (pq)-induced changes in the expression of cyclooxygenase-2 (cox-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. twenty four male wistar rats (180-200 g) were exposed either against saline as control group or var...

colon cancer is cancer of the large intestine (colon), the lower part of digestive system and the third most common cancer in men and the second most common cancer in women worldwide. genetic background is thought to play a role in modulating individual risk to this cancer. many studies support an association for insulin pathway gene polymorphisms and   the regulation of tumor cell biology in c...

background: considering the importance of updating information about incidence and mortality of common or fatal cancers and the need for studying the effectiveness   of   changes   in   the   iranian   cancer   registration   system   from pathological based to population based since 2007, the aim of this study was to provide updated population based information on incidence and mortality rates...

objectives: the aim of this study was to evaluate the effect of gutta percha/ah26 and resilon/realseal se on residual antimicrobial activity of chlorhexidine (chx) in human root dentin and suggest the best filling material when chx is used as final irrigant. materials and methods: one-hundred and forty-four single-rooted human teeth were selected for this study. canals were instrumented to the ...

objective: previous studies showed that grape seed extract (gse) is an excellent natural substance with potent antioxidant effect and free radical scavenger. this study aimed to evaluate the effect of gse on motor dysfunctions and thalamic local electroencephalography (eeg) frequency bands' powers in rats with parkinson's disease (pd). materials and methods: in this study 8 µg 6-hydro...