With an agreed success rate of about 85 per cent. the role of oral oxytetracycline hydrochloride in the treatment of non-specific urethritis was firmly established a decade ago. Other oral tetracyclines have proved of similar value. While the results obtained with intramuscular oxytetracycline and other tetracyclines have been comparable, the incidence of pain at the injection site has been suc...

We present a novel reflectance-based colorimetric aptasensor using gold nanoparticles for the detection of oxytetracycline for the first time. It was found that the reflectance-based measurement at two wavelengths (650 and 520 nm) can generate more stable and sensitive signals than absorbance-based sensors to determine the aggregation of AuNPs, even at high AuNP concentrations. One of the most ...

A simple, rapid fluorescence assay was developed for screening tetracyclines in chicken muscle at the U.S. tolerance level (2 mg/kg). The method requires only a homogenization of the tissue in acetonitrile-ammonium hydroxide, centrifugation, addition of Mg+2, and another centrifugation before fluorescence of the supernatant is measured at 505 nm (excitation at 385 nm). Comparison of the fluores...

The depletion times of enrofloxacin and its metabolite ciprofloxacin as well as sulfaquinoxaline and oxytetracycline were evaluated in broiler chickens that had been subjected to pharmacological treatment. The presence and residue levels of these drugs in muscle tissue were evaluated using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method that was validated...

Of 62 men with non-gonococcal urethritis who entered a study to assess compliance with treatment with oxytetracycline, only 33 could be evaluated. Traditional methods (interview and the absence of oxytetracycline in the urine) showed incomplete compliance in nine. Use of low dose phenobarbitone as a pharmacological marker showed incomplete compliance in a further five patients. In addition, phe...

Objectives: This study has been done to evaluate the interaction between ethanolic extracts of Rhus coriaria (seed), Psidium guajava (Leaf), Lawsonia inermis (Leaf) and Sacropoterium spinosum (seed) and antimicrobial drugs including oxytetracycline HCl, enrofloxacin, gentamicin sulphate and sulfadimethoxine against four clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). Me...

A study on the use of prophylactic antibiotics in gastro-intestinal surgery by veterinary practices in southwest Nigeria was conducted to evaluate current practices using structured questionnaire and a retrospective study of hospital care records. The results indicated that the use of prophylactic antibiotics in surgery was embraced by all practices with Amoxicillin>Oxytetracycline>Ciprofloxaci...

Clinical Borrelia theileri infection was reported for the first time in cattle from Botswana concurrent with Babesia bovis and Theileria mutans infections. Two animals, an ox and a cow of the Tswana breed demonstrated clinical signs of fever, haemoglobinuria, inappetance, diarrhoea, pallor of mucous membranes, enlarged superficial lymph nodes and rough hair coats. Examination of the blood smear...

This study aimed to investigate antibiotics resistance pattern and phenotyping of Aeromonas species isolated from different aquatic sources in Melaka, Malaysia. A total of 53 Aeromonas species were isolated from the following sources: sediment (n = 13), bivalve (n = 10), sea cucumber (n = 16) and sea water (n = 14) and resistance to 12 antibiotics - Tetracycline (30 μg), Kanamycin (30 μg), Oxyt...

A total of iz treatmct schcdules consbiing oxytetracycline and an alpha­ dithiosetnicarbazonew'ere tested in' 36 splcnectomizcd calves carrying Anaplasma marginale infections. Anaplasma itifrtion was elimiatcdfollo'in[g the administration of 5 or ionig./kg. dithiosemicarbazone combined with j img./lkq. oxytetracycline, and gi,en 3 times at 24 or 48 hr. intervals. Treatments employing ho'er drg"...