نتایج جستجو برای: oxypurinol

تعداد نتایج: 163  

Journal: :European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993
R Kock B Delvoux H Greiling

A method was developed for the simultaneous determination of hypoxanthine, xanthine, uric acid and allantoin based on isocratic reversed-phase chromatography. This HPLC-method additionally allows the direct determination with UV-detection of inosine-5'-phosphate, uridine, thymine, orotic acid, allopurinol and oxipurinol, besides hypoxanthine, xanthine and uric acid in the same chromatographic r...

Journal: :Structure 2002
James J Truglio Karsten Theis Silke Leimkühler Roberto Rappa K V Rajagopalan Caroline Kisker

Xanthine dehydrogenase (XDH), a complex molybdo/iron-sulfur/flavoprotein, catalyzes the oxidation of hypoxanthine to xanthine followed by oxidation of xanthine to uric acid with concomitant reduction of NAD+. The 2.7 A resolution structure of Rhodobacter capsulatus XDH reveals that the bacterial and bovine XDH have highly similar folds despite differences in subunit composition. The NAD+ bindin...

2006
Ariel J. Reyes

The recent article describing a positive association between serum uric acid and several inflammatory markers in the InCHIANTI study addresses the issue of whether uric acid is an independent cardiovascular risk factor. Uric acid is an antioxidant and appears to contribute to salutary immune reactions, but the cardiovascular significance of rises in its serum level remains poorly understood. I ...

2009
Jacob George Allan Struthers

Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high. The search for newer, novel ways of attenuating endothelial dysfunction has yielded several new and exciting possibilities, one of which is the manipulation of urate levels ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2002
Zsolt Bagi Zoltan Ungvari Akos Koller

We hypothesized that in hyperhomocysteinemia (HHcy), flow-induced arteriolar constriction is due to an enhanced generation of reactive oxygen and/or nitrogen species, causing an impairment of nitric oxide (NO) and prostaglandin mediation of the response. Changes in diameter of isolated, pressurized (at 80 mm Hg) gracilis muscle arterioles (diameter approximately 170 microm) from control and met...

Journal: :Hypertension 2010
Sven Wind Knut Beuerlein Melanie E Armitage Ashraf Taye Arun H S Kumar Daniel Janowitz Christina Neff Ajay M Shah Kirstin Wingler Harald H H W Schmidt

Arterial hypertension is associated with increased levels of reactive oxygen species, which may scavenge endothelium-derived NO and thereby diminish its vasorelaxant effects. However, the quantitatively relevant source of reactive oxygen species is unclear. Thus, this potential pathomechanism is not yet pharmacologically targetable. Several enzymatic sources of reactive oxygen species have been...

Journal: :Clinical chemistry 1974
E W Holmes D H Mason L I Goldstein R E Blount W N Kelley

Xanthinuria is a familial disorder of purine metabolism that results from a marked deficiency of xanthine oxidase (EC 1.2.3.2) activity. We report here the clinical and biochemical features of a new case of xanthinuria. Serum urate concentration was 0.8 mg/i 00 ml, urinary uric acid excretion was 16 mg per day, urinary oxypurme excretion was 1630 mol per day, and total purine excretion was 314 ...

Journal: :European heart journal 2006
Reyes J Ariel

The recent article describing a positive association between serum uric acid and several inflammatory markers in the InCHIANTI study addresses the issue of whether uric acid is an independent cardiovascular risk factor. Uric acid is an antioxidant and appears to contribute to salutary immune reactions, but the cardiovascular significance of rises in its serum level remains poorly understood. I ...

Journal: :American journal of physiology. Endocrinology and metabolism 2011
Amélie Bravard Charlotte Bonnard Annie Durand Marie-Agnès Chauvin Roland Favier Hubert Vidal Jennifer Rieusset

Reactive oxygen species (ROS) have been widely implicated in the pathogenesis of diabetes and more recently in mitochondrial alterations in skeletal muscle of diabetic mice. However, so far the exact sources of ROS in skeletal muscle have remained elusive. Aiming at better understanding the causes of mitochondrial alterations in diabetic muscle, we designed this study to characterize the sites ...

Journal: :Circulation 2007
André Dejam Christian J Hunter Carole Tremonti Ryszard M Pluta Yuen Yi Hon George Grimes Kristine Partovi Mildred M Pelletier Edward H Oldfield Richard O Cannon Alan N Schechter Mark T Gladwin

BACKGROUND The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the possibility that nitrite contributes to hypoxic vasodilation and to the bioactivity of nitroglycerin and mediates the cardiovascular protective effects of nitrate in the Mediterranean diet. However, important questions of potency, kinetics, mechanis...

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