The present study investigated the effects of co-administration of aspirin, metformin, atorvastatin and captopril on serum lipid profile and oxidative stress in the heart and kidney of streptozotocin-induced diabetic rats. In this study, rats were randomly divided into the following eleven groups: control (Cont.), and diabetic (D), as well as 9 groups that were treated with metformin (M, 300 mg...

Diabetic nephropathy (DN) has become an utmost reason for long-standing renal dysfunction and end-stage disease globally. Oxidative stress induced by persistent hyperglycemia is considered a fundamental element in the evolution of DN. The goal this research was to discover outcome appendages natural antioxidants such as lycopene co-enzyme Q10 (CoQ10) DN rats observe preventive effects A diabete...

Objectives: Cardiotoxicity is considered the primary cause of death in aluminum phosphide (ALP)-poisoned cases. Curcumin, the active ingredient of turmeric, is a potent protective polyphenol compound against cardiac diseases including cardiotoxicity. This study aimed to examine the probable cardioprotection potential of nanocurcumin in a rat model of ALP-induced cardiotoxicity. Methods: T...

Background: High concentrations of serum inflammatory and oxidative stress markers and lipid abnormities are important risk factors for cardiovascular diseases in hemodialysis patients. This study aims to investigate the effects of Nigella sativa oil on serum levels inflammation and oxidative stress markers and lipid profile in hemodialysis patients. Methods: Fifty hemodialysis patients partici...

Polycystic Ovary Syndrome (PCOS) is a reproductive, hormonal, and metabolic disorder frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress. Resveratrol naturally occurring polyphenolic stilbene found in trace amounts some food items. It has been extensively used as treatment option for disorders but its use PCOS limited. This review emphasizes t...

The aim of this study to establish the effect systemic N-acetylcysteine (NAC) administration on oxidative–antioxidative balance, inflammatory markers, and collagen production during wound healing in diabetes. A total 24 male Wistar albino rats were randomly divided into 4 groups: control, streptozotocin-induced diabetic model, NAC treatment group, model with treatment. dorsal circular was creat...

Exercise training causes increased oxidative stress. Pistacia Atlantica Extract (Mastic) is known to have a protective effect against oxidative stress and inflammation. We examined the effects of exercise training with and without Pistacia Atlantica extract administration on antioxidant markers in vistar rats. Twenty-eight Vistar female rats (six to eight weeks old, 150-200 g weight) allocate...

OBJECTIVE To explore the differences existing between the levels of oxidative stress in peripheral and mesenteric serum in patients with colorectal cancer. MATERIAL AND METHODS One hundred fifty patients with colorectal cancer who underwent surgery between May 2005 and March 2010 were prospectively analyzed. The differences between oxidative stress parameters in their peripheral and mesenteri...

background: lipid peroxidation is a free radical-generating process which occurs on every membranous structure of the cell. free radicals are known to be involved in a number of human pathologies including atherosclerosis. the purpose of this cross-sectional study was to examine the association between pre-hypertension status and oxidative stress markers [total antioxidant capacity (tac) and ma...

Affective disorders are a medical condition with a complex biological pattern of etiology, involving genetic and epigenetic factors, along with different environmental stressors. Increasing numbers of studies indicate that induction of oxidative and nitrosative stress (O&NS) pathways, which is accompanied by immune-inflammatory response, might play an important role in the pathogenic mechanisms...