Our laboratory is engaged in an ongoing analysis of a 103-compound data set containing reliable intravenous pharmacokinetic parameters in the rat, dog, monkey, and human, and we have previously reported our findings regarding extrapolation of clearance. In this article, we report on our findings regarding volume of distribution and mean residence time. Various allometric and nonallometric metho...

The basic idea in PRINCIPLES AND PARAMETERS THEORY is to distinguish the invariants of human language (the principles) from the major points of crosslinguistic variation (the parameters). Both principles and parameters are taken to reflect innately determined, biological characteristics of the human brain (see UNIVERSAL GRAMMAR). In the course of normal child development, however, the two diver...

We consider the correlation functions of the tachyon vertex operator of the super Liouville theory coupled to matter fields in the super Coulomb gas formulation, on world sheets with spherical topology. After integrating over the zero mode and assuming that the s parameter takes an integer value, we subsequently continue it to an arbitrary real number and compute the correlators in a closed for...

The first fully automated noise and S-parameter measurement bench is reported for W-band on-wafer characterisation. A calibration procedure is described that allows the receiver reference plane tc, be accurately moved to i:he probe tip.

Remnant low-energy effects of Planck-scale Lorentz breaking in candidate fundamental theories typically include modified one-particle dispersion relations. Theoretical constraints on such modifications are discussed leading to the exclusion of a variety of previously considered Lorentz-violating parameters. In particular, the fundamental principle of coordinate independence, the role of an effe...

This paper describes a model for the analysis of multilayered chiral structures containing planar electric and magnetic scattering elements of arbitrary shape, illuminated by an elliptically polarized plane wave. The particular case of a single chiral layer is analyzed and the scattering matrices for single and dual electric and/or magnetic dipole distributions are derived in an original way. A...

Coherent states in the time-energy plane provide a natural basis to study adiabatic scattering. We relate the (diagonal) matrix elements of the scattering matrix in this basis with the frozen on-shell scattering data. We describe an exactly solvable model, and show that the error in the frozen data cannot be estimated by the Wigner time delay alone. We introduce the notion of energy shift, a co...

This study was conducted to comprehensively survey the available literature on intravenous pharmacokinetic parameters in the rat, dog, monkey, and human, and to compare common methods for extrapolation of clearance, to identify the most appropriate species to use in pharmacokinetic lead optimization, and to ascertain whether adequate prospective measures of predictive success are currently avai...

This paper presents a procedure for allocating transmission cost to generators and loads. The procedure is based on the network Z-bus matrix. This work proposes three methods using bus impedance matrix Zbus. The three techniques are Zbus method, Zbus avg method and a newly proposed technique. The new method is very effective in transmission cost allocation A physically-based network usage proce...

We study the general L0-regular gl(2) spin chain, i.e. a chain where the sites {i, i + L0, i + 2L0, . . . } carry the same arbitrary representation (spin) of gl(2). The basic example of such chain is obtained for L0 = 2, where we recover the alternating spin chain. Firstly, we review different known results about their integrability and their spectrum. Secondly, we give an interpretation in ter...