نتایج جستجو برای: overloaded
تعداد نتایج: 3067 فیلتر نتایج به سال:
OBJECTIVE We investigated the effects of acute volume and RV pressure overload on biventricular function and gene expression of BNP, pro-inflammatory cytokines (IL-6 and TNF-alpha), iNOS, growth factors (IGF-1, ppET-1), ACE and Ca2+-handling proteins (SERCA2a, phospholamban and calsequestrin). METHODS Male Wistar rats (n=45) instrumented with pressure tip micromanometers in right (RV) and lef...
Fajardo VA, Rietze BA, Chambers PJ, Bellissimo C, Bombardier E, Quadrilatero J, Tupling AR. Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload. Am J Physiol Cell Physiol 313: C154–C161, 2017. First published June 7, 2017; doi:10.1152/ajpcell.00291.2016.—Overexpression of sarcolipin (SLN), a regulator of sarco(endo)plasmic reticulum Ca -ATPases...
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood. As renal prognosis in CKD is largely determined by the degree of renal tubular injury that correlates with residual proteinuria, we hypothesized that BM-MSCs may exert modulato...
It is well known that iron overload can result in pancreatic iron deposition, beta-cell destruction, and diabetes in humans. Recent studies in animals have extended the link between iron status and pancreatic function by showing that iron depletion confers protection against beta-cell dysfunction and diabetes. The aim of the present study was to identify genes in the pancreas that are different...
Prostacyclins are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostacyclins on right heart function are still not clarified. The aim of this study was to investigate the possible direct inotropic properties of clinical available prostacyclin mimetics in the normal and the pressure-overloaded human right atrium. Trabeculae from the right at...
Overloading in the context of higher-order logic has been used for some time now. Isabelle is the only proof-assistant that actually implements overloading within the logic instead of merely instrumenting the pretty-printing machinery on top of the logic. So far there existed no satisfying theory that could explain why it is safe to add a mechanism of certain kinds of possibly overloaded consta...
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