نتایج جستجو برای: overexpression

تعداد نتایج: 75121  

Journal: :Molecular Biology of the Cell 2015

Journal: :iranian journal of basic medical sciences 0
razieh pourahmad jaktaji department of genetics, faculty of science and biotechnology center, university of shahrekord, shahrekord, iran nasim jazayeri students in genetics at university of shahrekord

objective(s): the major antibiotic efflux pump of esherichia coli is acrab-tolc. the first part of the pump, acrab, is encoded by acrab operon. the expression of this operon can be kept elevated by overexpression of an activator, mara following inactivation of marr and acrr repressors due to mutation in encoding genes, marr and acrr, respectively. the aims of this research were to use e. coli m...

Journal: :iranian journal of basic medical sciences 0
mahsa mohseni research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran department of medical biotechnology, faculty of advanced medical sciences, tabriz university of medical sciences, tabriz, iran nasser samadi research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran department of medical biotechnology, faculty of advanced medical sciences, tabriz university of medical sciences, tabriz, iran department of biochemistry and clinical laboratories, faculty of medicine, tabriz university of medical sciences, tabriz, iran parisa ghanbari research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran

objective(s): chemoresistance remains the main causes of treatment failure and mortality in cancer patients. there is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. induction of drug efflux due to overexpression of                  p-glycoproteins is considered as an important leading cause of multidrug resis...

Journal: :research in pharmaceutical sciences 0

dna methylation plays an important role in carcinogenesis through epigenetic silencing of tumor suppressor genes. aberrant methylation usually results from changes in the activity of dna methyltransferases (dnmts). some studies show that the overexpression of the dnmts may lead to aberrant methylation of tumor suppressor genes. also the overexpression of dnmts may be related to methylation stat...

Journal: :reports of biochemistry and molecular biology 0
omid azizi department of microbiology and virology, kerman university of medical sciences, kerman, iran fereshteh shahcheraghi department of bacteriology, pasteur institute of iran, tehran, iran himen salimizand department of microbiology and virology, kurdistan university of medical sciences, kurdistan, iran farzan modarresi department of microbiology, school of medicine, jahrom university of medical sciences, jahrom, iran mohammad reza shakibaie tel: +98 9133408226; fax: +98 34 33221671 shahla mansouri department of microbiology and virology, kerman university of medical sciences, kerman, iran

background: acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. in this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm...

Journal: :modares journal of medical sciences: pathobiology 2011
fatemeh zolghadr majid sadeghizadeh naser amirizadeh mehrdad behmanesh saman hosseinkhani

objective: evaluating the effects of p-benzoquinone and hydroquinone on the runx2 expression and osteoblastic differentiation of human marrow derived mesenchymal stem cells (mscs). materials and methods: bone marrow mscs obtained by cultivating marrow mononuclear cells, were exposed to 10μm of either p-benzoquinone or hydroquinone. following chemical treatment, runx2 gene expression was assess...

Journal: :acta medica iranica 0
hamed montazeri department of molecular biology, pasteur institute of iran, tehran, iran. saeid bouzari department of molecular biology, pasteur institute of iran, tehran, iran. kayhan azadmanesh department of virology, pasteur institute of iran, tehran, iran. seyed nasser ostad department of toxicology pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mohammad hossein ghahremani department of toxicology-pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. and department of molecular medicine, school of advanced technology in medicine, tehran university of medical sciences, tehran, iran.

cyclin e, her-2 and p53, are considered as major prognostic markers in breast cancer. as they are related in patho-clinical level, we aimed to check if they have any direct interaction on expression of each other. to study the effect of cyclin e on her-2 expression, cell lines stably overexpressing cyclin e or its low molecular weight (lmw) isoforms were generated. to understand the results of ...

Journal: :Cancer Cell International 2009

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