OBJECTIVE: The aim of this study is to evaluate the outcomes gonadotropin-releasing hormone agonist treatment for ovarian cysts, which are developed during tamoxifen use due breast cancer. STUDY DESIGN: This was a retrospective cohort including patients who were under stage I-III cancer and administered leuprolide acetate cysts with low malignancy risk between 2012-2020. RESULTS: Leuprolide tot...

Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known about how the cancer initiates and metastasizes. In the last decade, new evidence has challenged the dogma that the ovary is the main source of this cancer. The fallopian tube has been proposed instead as the primary origin of high-grade serous ovarian cancer, the subtype causing 70% of ovarian cancer de...

Background: North East is the “cancer capital” of India where there acute lack oncologists and oncology facilities. Objectives study were to evaluate trends gynecological malignancies need for facility in Sikkim.Methods: This a retrospective desk review conducted department obstetrics gynecology at Sikkim Manipal institute medical sciences, India, period three years after start surgeries. Women...

common yew taxus baccata l. is an evergreen, slow growing   tree, indigenous of hyrcanian forests in iran. discovery of paclitaxel as an   anti tumor agent in the bark of taxus has increased importance of this   plant for treatment of breast and ovary cancer, especially 7000 women die annually   due to breast cancer in iran. regarding destructive method of paclitaxel   production and protection...

PURPOSE The pattern of breast cancer metastasis may be determined by interactions between CXCR4 on breast cancer cells and CXCL12 within normal tissues. Glycosaminoglycans bind chemokines for presentation to responsive cells. This study was designed to test the hypothesis that soluble heparinoid glycosaminoglycan molecules can disrupt the normal response to CXCL12, thereby reducing the metastas...

Here, we found that ING5 overexpression suppressed cell viability, glucose metabolism, migration, invasion and epithelial-mesenchymal transition, and induced cell arrest, apoptosis, senescence, autophagy and fat accumulation in ovarian cancer cells. ING5-mediated chemoresistance was positively linked to apoptotic resistance and chemoresistance-related gene expression. ING5 overexpression suppre...

Significant elevations in plasma/serum lipid bound sialic acid (LSA) concentrations have been documented in patients with malignant diseases. Initial studies indicate that LSA may be a useful marker in cancer of the prostate, bladder, breast, lung, colon, ovary and in leukemia, lymphoma, Hodgkins disease and melanoma. The data suggest that the LSA test lacks the required sensitivity and specifi...

Women at increased risk for breast cancer are at increased risk for ovarian cancer as well, reflecting common risk factors and intertwined etiology of the two diseases. We previously developed a rat model of elevated breast and ovarian cancer risk, allowing evaluation of dual-target cancer prevention strategies. Tamoxifen, a Food and Drug Administration-approved breast cancer chemoprevention dr...

Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA le...

This study compares cancer incidence in the United States National Survey areas and Puerto Rico for the period of 1969 to 1974. There are several differences between the 2 areas. Puerto Rico has a higher incidence of cancer of the mouth, pharynx, esophagus, stomach, cervix uteri, vulva, and penis. The Survey areas have higher incidences of cancer of the colon, rectum, lung, corpus uteri, female...