We show here that elevated levels of gonadotropins (luteinizing hormone and follicle stimulating hormone), as found in menopause or after ovariectomy, promote growth of human ovarian carcinoma by induction of tumor angiogenesis. Human epithelial ovarian cancer tumors progressed faster in ovariectomized mice. This induced growth could be attributed to the elevated levels of gonadotropins associa...

Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene-protein analysis of the ovarian transition to menopause, we have established and contrasted RNA gene expressio...

objective: recently the laparoscopic ovarian drilling (lod) has been used as a surgical treatment for ovulation in women with polycystic ovarian syndrome (pcos), although its mechanism and outcomes are still unclear. this study was undertaken to evaluate the in vitro fertilization (ivf)/intracytoplasmic sperm injection (icsi) outcomes in clomiphene-resistant women with pcos who were treated wit...

The early decline and loss of female fertility in humans and other species represents an evolutionary paradox. Despite being born with a vast stock of oocytes, females encounter an exhaustion of ovarian reserve and sterility half way through their natural lives. Female reproductive ageing has been proposed to proceed as an ongoing decline in ovarian reserve, determined by remaining ovarian foll...

Background: Aqueous extract of winter cherry (Physalis alkekengi L; family of Solanaceae) fruits (WCF) has long been recommended for fertility control by herbalists in Iran. The effect of this extract on lowering serum progesterone levels has been reported previously. Objective: To study the effects of WCF extract on the activities of ovarian 3β-hydroxysteroid dehydrogenase (3β-HSD) responsible...

background: one the main aspects of an in vitro fertilization (ivf) cycle is to avoid any possible systemic damage to women undergoing to a controlled ovarian hyperstimulation (coh). the aim of this work is to evaluate renal and hepatic function blood tests in patients undergoing controlled ovarian hyperstimulation during ivf cycles. materials and methods: all patients received a long stimulati...