OBJECTIVE To determine the effect of estrogen replacement therapy (ERT) on the vaginal flora of postmenopausal women. METHODS Vaginal cultures were obtained from 15 postmenopausal women whose hormonal statuses were documented by serum follicle-stimulating hormone (FSH) and serum estrogen levels. After 8 weeks of ERT, consisting of 0.1 mg of estradiol delivered daily by dermal patch, the vagin...

BACKGROUND AND OBJECTIVES Primary hypothyroidism may be associated with ovarian enlargement and/ or cyst formation. We evaluated the effect of thyroid hormone replacement therapy on hormonal changes, ovarian volume and sonographic appearance. DESIGN AND SETTING Open, prospective study of women admitted to university gynecology clinic. PATIENTS AND METHODS The study included 26 patients with...

Proper education and notification of patients undergoing heart valve replacement is of paramount importance. The past decade has witnessed a growing interest in the use of modern, advanced technologies in medicine and patient education. This study aimed to introduce an education-notification application for patients undergoing heart valve replacement. Research was carried out in two phases of s...

OBJECTIVE Ovarian senescence affects many tissues and produces a variety of symptoms and signs. We hypothesized that estrogens may also influence circulating redox balance by regulating activity of the cellular antioxidative enzyme system. We aimed to explore the impact of surgical estrogen deprivation and replacement (ERT) on the glutathione balance and antioxidant enzymes expression in fertil...

BACKGROUND The study was carried out to evaluate the effects of short-term transdermal hormone replacement therapy (HRT) on glycaemic control, lipid metabolism, C-reactive protein (CRP) and proteinuria in high-risk postmenopausal women. METHODS A total of 20 well-controlled type 2 diabetic, hypertensive and 21 well-controlled glucose-tolerant, hypertensive postmenopausal women were prospectiv...

BACKGROUND Appropriate utilization of vancomycin is important to attain therapeutic targets while avoiding clinical failure and the development of antimicrobial resistance. Our aim was to observe the use of vancomycin in an intensive care population, with the main focus on achievement of therapeutic serum concentrations (15-20 mg/l) and to evaluate how this was influenced by dose regimens, use ...

the aim of this study was to investigate the prevalence of mg deficiency and effect of aminophylline infusion on urine magnesium concentration after magnesium loading test (mlt). to determine serum mg, venous blood specimens were obtained just before the first mlt. two mlts were performed. the first one was done before starting aminophylline infusion and the 2nd one was done during aminophyllin...

BACKGROUND Acute kidney injury is a common and devastating complication of critical illness, for which renal replacement therapy is frequently needed to manage severe cases. While a recent systematic review suggested that "earlier" initiation of renal replacement therapy improves survival, completed trials are limited due to small size, single-centre status, and use of variable definitions to d...