AIM Our aim was to determine serum concentrations of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its decoy receptor osteoprotegerin (OPG) in patients with mild and moderate to severe acute pancreatitis (AP) in the early phase of the disease. MATERIALS AND METHODS We included 40 patients with AP (16 women, 24 men) admitted to Ist Department of Surgery, Jagiellonian Univ...

OBJECTIVE Osteoprotegerin ligand (OPGL) is a newly discovered molecule, which is expressed by osteoblasts/bone stromal cells. This ligand and M-CSF are now known to be essential for osteoclast differentiation from marrow and circulating precursors. This study examined whether OPGL and its soluble receptor osteoprotegerin (OPG), influenced osteoclast formation from human arthroplasty derived mac...

Aging is associated with the development of both osteoporosis and vascular disease, and there is increasing evidence for a link between bone metabolism and the vasculature.1 A number of cross-sectional and longitudinal studies have demonstrated inverse, independent associations between bone mineral density and vascular calcification,2–5 which appear to be predictive of atherosclerosis and relat...

In this study, we used a substance P (SP) immunohistochemical method to analyze the expression localization of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) in giant cell tumor (GCT) of the bone, and to detect the clinical significance of their expression. The data showed that the positive expression rate of OPG in the multinucleated giant cells (MGCs) and stromal cells (STCs) of GCT ...

Background Osteoprotegerin (OPG) is an intrinsic antagonist of the RANKL. A recent study reported that RANKL reverse signaling in osteoblasts may prepare for further maturation and vesicular RANK stimulates osteoblast differentiation. Hence, OPG expected to accelerate osteoblastogenesis by affecting signaling. Objectives We compared level differentiation from preosteoblasts serially administrat...

Osteoclast function is important in the development of renal osteodystrophy (ROD). Osteoclast activity is modulated by the osteoprotegerin ligand-osteoprotegerin (OPGL/OPG) system. In the present study, we checked levels of serum OPG and soluble OPGL in dialyzed patients and correlated those levels with routinely measured parameters of bone metabolism. The study was carried out in 39 patients o...

The integrity of the skeleton depends upon bone remodeling, the permanent and controlled resorption of bone by osteoclasts (OC) and its subsequent replacement by bone-forming osteoblasts. An imbalance between bone resorption and bone formation results in osteoporosis (if bone resorption exceeds bone formation) or osteopetrosis (if bone formation exceeds bone resorption). The regulation of the b...