The femoral head deteriorates in osteonecrosis. As a consequence of that, the cortical shell of the femoral head can buckle into the cancellous bone supporting it. In order to examine the buckling scenario we performed numerical analysis of a realistic femoral head model. The analysis included a solution of the hip contact problem, which provided the contact pressure distribution, and subsequen...

thy, characterized by severe joint destruction occurring within a few months, is ascribed to subchondral insufficiency fracture resulting from osteoporosis1 and ischemic hip disease.2 Corticosteroids can cause avascular osteonecrosis of the femoral head, osteoporosis, or both. Most cases of corticosteroid-induced osteonecrosis are caused by exogenous corticosteroid administered for the treatmen...

Hemoglobin SC disease is characterized by less severe morbidity than in homozygous form. Nevertheless vaso-occlusive crisis was reported to be less frequent, some chronic complications are more frequent, such as retinopathy and osteonecrosis of femoral head. This study aimed to describe the chronic complications of Hb SC disease patients and to identify associated predictive factors. This cohor...

The mechanism of steroid-associated femoral head necrosis remains unclear. The present study investigated the role of microRNA-23a-3p (miR-23a-3p) in the incidence of osteonecrosis in a rat model. An miR-23a-3p mimic, an inhibitor and a negative control were transfected into bone mesenchymal stem cells using a lentiviral vector, and then injected into the steroid-induced femoral head necrosis m...

Avascular osteonecrosis of the femoral head (ONFH) is one causes hip pain that clinicians need to know about. In many cases, it a fortuitous discovery when pelvic X-rays performed for another reason. other reveals disease. For rheumatologist, major part job look cause. An etiology can be found ONFH in about 70% cases. Some them are evident and context give diagnosis (corticosteroids, alcohol ab...

Steroid induced osteonecrosis is a devastating injury that usually requires rebuild of the joint, with the femoral and the humeral head being most commonly affected. Steroid therapy is the most common reported cause of atraumatic osteonecrosis. The Collaborative Osteonecrosis Group Study confirmed that steroids are the primary cause of multi-focal osteonecrosis in 91% of the cases. Osteonecrosi...