BACKGROUND The aim of this study was to estimate the prevalence of gross pathology suggestive of bovine tuberculosis (TB-like lesions) and evaluate animal's characteristics associated with the risk of having bovine TB-like lesions among cattle slaughtered in Mubende district in the Uganda cattle corridor. METHOD We conducted a cross sectional study in which 1,576 slaughtered cattle in Mubende...

Understanding how seasonality shapes the dynamics of tuberculosis (TB) is essential in determining risks of transmission and drug resistance in (sub)tropical regions. We developed a relative fitness-based multidrug-resistant (MDR) TB model incorporated with seasonality and a probabilistic assessment model to assess infection risk in Taiwan regions. The model accurately captures the seasonal tra...

The National Notifiable Diseases Surveillance System received 1,194 tuberculosis (TB) notifications in 2008 and 1,322 notifications in 2009. The incidence of TB in Australia was 5.6 cases per 100,000 population in 2008 and 6.0 per 100,000 in 2009, similar to rates since 1986. In both 2008 and 2009, more than 85% of cases occurred in the overseas-born population. The incidence in the Australian-...

BackgroundLinezolid presents strong antimicrobial activity against multidrug-resistant (MDR) pulmonary tuberculosis (TB), but its application in osteoarticular treatment remains understudied. Our objective was to analyze the bone penetration efficiency of linezolid TB patients.MethodsOsteoarticular patients, treated with 600 mg q 24 h linezolid-containing regimens and undergoing surgery, were p...

BACKGROUND Inadequate knowledge and wrong perception of multidrug-resistant tuberculosis (MDR-TB) by Health Care Workers (HCWs) and patients are detrimental to tuberculosis control programs. OBJECTIVE The aim was to assess the knowledge and attitudes of HCWs and TB patients about MDR-TB in Delta State, Nigeria. MATERIALS AND METHODS A cross-sectional study was carried out among HCWs and TB ...

Multidrug-resistant strain of Mycobacterium tuberculosis (MDR-Tb) and Multidrug-sensitive Mycobacterium tuberculosis (MDS-Tb) isolated from humans were injected subcutaneously into the guinea pigs. One set of infected lungs of animals was fixed in 10% formalin pH7.2, while the other set was treated with 75% ethanol 2 hours prior to fixation in 10% formalin. After six months of fixation, MDS-Tb ...

A series of 17 children presenting at Baragwanath Hospital with histologically proven osteo-articWar tuberculosis is reported. The relatively early stage in the disease process has led to a specific radiological appearance. However, confirmation ofdiagnosis at biopsy is made more difficult as the area actually infected by the tubercle bacillus may be extremely limited. Care in biopsy technique ...