In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situati...

The differentiation and functions of osteoclasts are regulated by receptor activator of nuclear factor-κB (RANK)/receptor activator of nuclear factor-κB ligand (RANKL) system that stimulates osteoclasts formation. Macrophage colony-stimulating factor (M-CSF) is also essential for osteoclastogenesis. A recent immunocytochemical study reported that RANKL/RANK and M-CSF/c-fms were localized in the...

Functionality and aesthetics are key considerations in patients requesting, and orthodontists recommending, orthodontic treatment. However, patients may elect to forego orthodontic treatment due to the cost and the duration of treatment. Orthodontic treatment can be provided using removable or fixed orthodontic appliances (FOAs), and current options offer improved aesthetics compared to earlier...

Objective(s): To investigate the effect of cocoa on orthodontic tooth movement (OTM) rate, osteoprotegerin (OPG), and receptor activator of nuclear factor κ β ligand (RANKL) levels after OTM.Materials and Methods: A total of 24 Sprague-Dawley rats were included in the study. They were equally divided into two groups: cocoa and control. The upper incisors of all rats were subjected to 35 cN orth...

This review article encompasses the literature pertaining to changes in dental pulp subsequent forces exerted secondary orthodontic treatment. The was conducted at College of Dentistry, Qassim University, Saudi Arabia, from October 2022 February 2023. A search on PubMed, Embase, Cochrane Library and Google Scholar for articles 2000 Keywords MeSH terms used were ‘orthodontic forces’, ‘pulp chang...

AIM Profiles of orthodontic tooth movement biomarkers, i.e., Lactate Dehydrogenase (LDH), Aspartate Aminotransferase (AST), Tartrate-resistant Acid Phosphatase (TRAP) and Alkaline Phosphatase (ALP), using Self-ligating Brackets (SLBs) and possible relationships among their activities and total enzymes produced were determined. METHODS Saliva and Gingival Crevicular Fluid (GCF) were collected ...

Previously, we discovered that periodontal ligament (PDL) cells not only support osteoclastogenesis through cell-to-cell contact, but also inhibit the formation of tartrate-resistant acid phosphatase-positive (TRAP+) multinucleated cells by a producing soluble factor(s). Furthermore, PDL cells express both receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) mess...

This in vitro study evaluated the Influence of prestretching, in the force decay of orthodontic elastic chains, at three time intervals: 2, 7 and 30 days with the brands Morelli, Orthometric and American Orthodontics. In the experimental group, prestretching was performed, stretching the elastics to increase them by 50% of their original length three times in a quick and sequential mode. All of...

Near the end of their letter, Brezniak et al quoted a sentence from our conclusion section and suggested that the conclusion is inappropriate. However, immediately preceding the quoted sentence, we wrote ‘‘Based on those findings, we might not be able to make definite predictions on the effect of these differences on the actual tooth movements. However, it is safe to conclude that different for...