Neither the mechanisms that govern lip morphogenesis nor the cause of cleft lip are well understood. We report that genetic inactivation of Lrp6, a co-receptor of the Wnt/beta-catenin signaling pathway, leads to cleft lip with cleft palate. The activity of a Wnt signaling reporter is blocked in the orofacial primordia by Lrp6 deletion in mice. The morphological dynamic that is required for norm...

Background Oral cleft is the most common orofacial congenital anomaly among live births. This anomaly at birth is one of the main causes of children disability and mortality.  Congenital heart disease (CHD) is one of the most common anomalies in oral clefts.  This study aimed to assess the incidence of congenital heart diseases anomalies in newborns with oral clefts. Materials and Methods This ...

Treacher Collins syndrome (TCS) is a rare autosomal dominant disorder of craniofacial development. Major features include midface hypoplasia, micrognathia, microtia, conductive hearing loss, and cleft palate. The present study is on the orofacial features of 7 Brazilian patients with sporadic TCS aged 4 to 38 years. All patients presented the typical down-slanting palpebral fissures, colobomas,...

Abstract Cleft births surveillance is essential in healthcare and prevention planning. Data are needed precision medicine to target upstream management for at-risk individuals. This study characterizes Singapore’s population-based orofacial cleft topography by ethnicity gender, establishes the cohort’s infant mortality rate. Data, decade 2003 2012, were extracted National Birth Defects Registry...

Introduction Cleft lip and palate (CLP) is one of the most common types of congenital malformation. Cleft lip is caused by failure of fusion of the median and lateral nasal processes while cleft palate (CP) is caused by failure of fusion of the palatal shelves of the maxillary process. The mean incidence of orofacial clefts locally over the past 10 years is 0.2%. The aetiology of CLP is multifa...

INTRODUCTION Cleft lips and palates are the most common congenital orofacial anomaly. This type of clefts is the most severe from the orthodontic-surgical therapy aspect. CASE REPORT A female newborn with a complete cleft of the primary and the secondary palate was admitted to the clinic, where a multiple-role orthodontic device was specially designed and applied to primarily manage the closu...

Correspondence to: Francesco Carinci, MD Chair of Maxillofacial Surgery University of Ferrara Arcispedale S. Anna Corso Giovecca, 203 44100 Ferrara Italy Phone/Fax: +39.0532.455582 Web: www.carinci.org E-mail: [email protected] Abstract Nonsyndromic orofacial cleft (OFC) derives from an embryopathy with failure of the nasal processes and/or fusion of the palatal shelves. This severe birth defect is...

Orofacial clefts, specifically cleft lip and/or cleft palate (CL/P), are among the most common congenital anomalies. CL/P vary in their location and severity and comprise 3 overarching groups: cleft lip (CL), cleft lip with cleft palate (CLP), and cleft palate alone (CP). CL/P may be associated with one of many syndromes that could further complicate a child's needs. Care of patients with CL/P ...

PURPOSE Because the true prevalence of food allergy (FA), as based on the results of an oral food challenge test (OFC), is unknown, it is likely that children with suspected FA unnecessarily eliminate potentially causative foods. This study aimed to identify the prevalence of FA and to determine the proportion of children who unnecessarily eliminate food. METHODS To identify children with FA,...

Previous studies suggest that the risk of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate (CP) is influenced by genetic variation at several loci and that the relation between specific genetic variants and disease risk may be modified by environmental factors. The present study evaluated potential associations between CL+/-P and CP and two putative cleftin...