The origin of life, based on the homochirality biomolecules, is a persistent mystery. Did life begin by using both forms chirality, and then one disappeared? Or did choice precede formation biomolecules that could ensure replication information transfer? Is natural L-amino acids D-sugars which deterministic or random? handedness present in/of Universe from its beginning? whole biosystem Earth, ...

In origins of life research, it is important to understand the difference between conjecture and hypothesis. This commentary explores the difference and recommends alternative hypotheses as a way to advance our understanding of how life can begin on the Earth and other habitable planets. As an example of how this approach can be used, two conditions have been proposed for sites conducive to the...

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Elizabeth S. Maywood,1 Johanna E. Chesham,1 Qing-Jun Meng,2 Patrick M. Nolan,3 Andrew S. I. Loudon,2 and Michael H. Hastings1 1Division of Neurobiology, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom, 2Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom, and 3Mammalian Genetics Unit, MRC Harwell, Oxfordshire ...