Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcryst...

OBJECTIVE To assess compliance with oral lansoprazole disintegrating tablets (LODT) in patients treated by traumatology specialists. MATERIAL AND METHOD A multicenter, observational, cross-sectional study involving 370 traumatology specialists and patients aged 18 or more. Study logistics were sponsored by Almirall Laboratories, S.A.; neither investigators nor patients received any economic c...

Orally disintegrating tablets of Furosemide were prepared, evaluated and the comparison action different concentrations disintegrants on disintegration dissolution studied. Direct compression method was used to prepare orally containing 20 mg Furosemide. The formulation conducted using crospovidone, croscarmellose sodium starch glycolate as superdisintegrants their interactions with also FTIR. ...

Mouth dissolving tablets are solid dosage forms containing drugs that disintegrate in the oral cavity within less than one minute leaving an easy-to-swallow residue. In the recent trend the development of mouth dissolving tablets formulation is emerging and gaining popularity because it is easy to administer and leads to better patient compliance. These dosage forms are placed in the mouth, all...

The demand of fast disintegrating tablets has been growing during the last decade, due to the characteristics of fast disintegrating sublingual tablets for the potential emergency treatment. In terms of permeability, the sublingual area of the oral cavity (i.e, the floor of the mouth) is more permeable than the buccal (cheek) area, which in turn is more permeable than the palatal (roof) of the ...

rapidly disintegrating oral tablets that contain disintegrants, such as microcrystalline cellulose or low substituted hydroxypropylcellulose. However, the main disadvantage of these tablets is a rough feeling in the mouth, because they are water-insoluble. To solve this problem, we used water-soluble sugars as ingredients of rapidly disintegrating oral tablets and developed a preparation method...

The purpose of the present study was to develop oral dispersible tablets containing prednisolone (PDS)-loaded chitosan nanoparticles using microcrystalline cellulose (MCC 101), lactose, and croscarmellose sodium (CCS). The PDS-loaded chitosan nanoparticles were formulated by ionotropic external gelation technique in order to enhance the solubility of PDS in salivary pH. Prepared nanoparticles w...

Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of salbutamol sulphate for respiratory disorders for pediatrics. As precision of dosing and patient's compliance become important prerequisites for a long-t...