OBJECTIVE To evaluate differences in swallowing physiology and safety in patients with dysphagia between conventional tablets and a new method of tablet transportation, orally disintegrating technology (ODT) (RapiTab; Schwarz Pharma Inc, Milwaukee, Wis). DESIGN The study observed a single group, crossover design. SETTING Outpatient clinic within an academic teaching hospital. PARTICIPANTS...

The purpose of this study was to investigate the applicability of our newly developed technology (RACTAB® technology) for preparing orally disintegrating tablets (ODTs) containing enteric-coated particles. Tamsulosin hydrochloride (TAM) was used as a model drug contained in the enteric-coated particles. Enteric-coated particles containing TAM (ECP-T) were prepared by spray coating a mixture of ...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

The purpose of this research was to mask the intensely bitter taste of diclofenac sodium and to formulate an orally-disintegrating tablet (ODT)) of the taste-masked drug. The methods commonly employed for achieving effective taste masking include various physical and chemical methods that prevent the drug substance from interaction with the taste buds. In this present study we have used veegum(...

INTRODUCTION It has become apparent, in the recent past, that vibration within the tablet dissolution testing environment is a real issue. Although this may not have been too apparent in normal routine dissolution testing, the real impact of vibration has become a focal point as a result of the Prednisone “Calibrator Tablet” tests, which generally have to be performed every six months on each i...

CLARITIN Tablets contain 10 mg micronized loratadine, an antihistamine, to be administered orally. It also contains the following inactive ingredients: corn starch, lactose, and magnesium stearate. CLARITIN Syrup contains 1 mg/mL micronized loratadine, an antihistamine, to be administered orally. It also contains the following inactive ingredients: citric acid, edetate disodium, artificial flav...