Telomerase is a ribonucleoprotein that maintains telomere length and whose activity is associated with escape from cellular senescence. Telomerase activity has been found in germline, immortalized, and malignant tumor cells. Using a modified PCR-based assay for telomerase activity, 26 of 35 (80%) primary, fresh, head and neck squamous cell cancer specimens and 3 of 6 head and neck squamous dysp...

abstract: introduction & objective: awareness of invasion of the walls of the cervical vessels by tumor is of great clinical importance before surgery. this study was designed to assess the diagnostic worth of computed tomography (ct) in distinguishing jugular vein (jv) invasion by oral –maxillofascial and neck malignant tumors. material & methods: ct with contrast was performed on 46 patients ...

Background: Oral cancer has a profound impact on quality of life, but the relationship between quality of life and tumorigenesis, catecholamine levels, and disease stage in oral cancer patients is not well understood. Methods: Pre-surgical quality of life was determined using the Short Form 36 (SF-36) health-related quality of life questionnaire in 75 oral neoplasm patients, including 40 oral c...

Schwannoma is a rare benign neural neoplasm derived from Schwann cells of the peripheral nerve sheath. Schwannoma accounts for 25% to 48% of all neoplasm cases in the head and neck region. Oral Schwannoma is an uncommon soft tissue tumor comprising of 1% of all Schwannomas. Tongue is the most common location for oral schwannoma. Occurrence of gingival schwannoma is very rare and less than 10 ca...

Phosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the induces hypophosphatemia leading oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT occurring in oral maxillofacial regions extremely r...

Background: The oral cavity is one of the most common sites for various tumors and tumor like lesions. Among the malignant lesions, squamous cell carcinoma is single most common malignant lesion of this region. Aims and Objectives: To study the histopathology of different tumor and tumor like lesion of oral cavity with relation to age, sex , site and risk factors involved in these lesions. Mate...

background: imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including oral cancer. majority of oral cancer are preceded by a well-recognized group of pre-malignant lesions. however, only a small fraction of those lesions, undergo malignant transformation. hence, there is a great need to identify biological markers, which will assis...