introduction: as a result of aging process, oral mucosa becomes susceptible to oral diseases. having knowledge about prevalence and distribution of geriatric oral diseases is essential for prevention and treatment planning. this study aimed to evaluate the prevalence of geriatric patients' oral biopsies in specimens obtained in medical centers of zahedan university of medical sciences. methods:...

Increased expression of Bcl-2 protein has been demonstrated in various cancerous and precancerous lesions. The B-cell lymphoma-2 gene is a proto-oncogene that inhibits apoptosis, therefore keeping the cell alive. Mutations leads to an overexpression products leading apoptosis impairment resulting neoplastic changes as consequence. Hence, objective study was investigate fibro epithelial polyp (F...

BACKGROUND The re-expression of pluripotent markers (Oct-4 and Nanog) and the reactivation of stem cell-related pathways in oral carcinoma have been well researched. However, the relationship between the stem cell signaling molecule β-catenin and pluripotent markers Oct-4 and Nanog in oral cancer is yet to be studied in detail. Therefore, we have investigated the correlation among Oct-4, Nanog,...

To analyze the clinical symptoms and signs in cases of oral submucous fibrosis which has transformed into squamous cell carcinoma, twenty-nine patients with squamous cell carcinoma correlated with oral submucous fibrosis, leukoplakia, lichen planus were taken biopsy for positive diagnosis. The clinical and pathological diagnosis of oral submucous fibrosis depended on clinical and pathological d...

background and aims. vascular endothelial growth factor (vegf) and ki-67 antigen are contributing factors in this process cell proliferation and new blood vessels formation in tumor progression. this study was conducted to examine the relationship between the expression of vegf and ki-67 and gender and age of patients with oral squamous cell carcinoma (oscc). materials and methods. twenty-three...

objective: a number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. it has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (no) production. these data suggest that the cytotoxic effect of saffron extra...

Spindle cell Carcinoma is a rare biphasic neoplasm consisting of epithelial and mesenchymal components and accounts for less than 1% of all tumours of oral region. It is a rare aggressive variant of squamous cell carcinoma which frequently recurs and metastasizes with poor prognosis compared to classical squamous cell carcinoma. The biologic behaviour is comparable to poorly differentiated Squa...

a primary intraosseous carcinoma (pioc) is a squamous cell carcinoma arising within the  jawbone andshould be differentiated from a malignant ameloblastoma.  it  is not due to arising from an odontogenic cyst or tumor. the possibility of the lesion being  a metastasis fromanotherprimary site should be considered, and excluded by a careful history and examination. the diagnosis of a pioc is rare...

Oral squamous cell carcinoma is rare in the pediatric population. When it does occur, it is most commonly seen on the tongue or lip. In this article, we report a rare case of squamous cell carcinoma of the maxillary gingiva and alveolus in a 10-year-old girl and review the literature concerning oral squamous cell carcinoma in the pediatric population.