BACKGROUND Angiotensin-converting enzyme inhibitors (ACEIs) are a mainstay of medical management in pediatric cardiology. However, there are no data defining how best to initiate and uptitrate the dose of these medications in children. METHODS AND RESULTS Retrospective chart review revealed only 24% of our pediatric cardiology inpatients were discharged on predefined optimal doses of ACEIs an...

Combination of drugs can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Current clinical approaches to combination therapy are mainly based on trial and error and reveal major toxicity issues. We applied a feedback system control (FSC) technique with a population-based stochastic search algorithm to navigate through the large parametr...

Introduction: Nowadays, spermatogonial stem cells (SSCs) cultivation has been used by many researchers as an effective tool for infertility treatments. Oxidative conditions can be effective on cell proliferation and differentiation of these cells. So, the aim of this study was to establish oxidative stress model for antioxidant activity of some drugs investigation during SSCs in vitro culture. ...

Background and Aims: Interferon alpha is an effective cytokine in viral infections, where it has various roles in immune function. The use of this antiviral agent in the treatment of viral infections and even cancers is common, although, the beneficial effects of this antiviral agent in high doses can be associated with side effects that limit its use. In this project, we tried to investigate t...

The intensification of crop production coupled with current declining soil fertility needs proper plant nutrition management and improved effectiveness fertilizer use. Sustainable practices providing new amendments could be a useful tool to improve productivity causing economic benefits. technology processing local raw materials (leonardite, bentonite, molasses) was developed produce optimal ph...

Penicillum janthinellum SDX7 was isolated from aged petroleum hydrocarbon-affected soil at the site of Anand, Gujarat, India, and was tested for different pH, temperature, agitation and concentrations for optimal growth of the isolate that was capable of degrading upto 95%, 63% and 58% of 1%, 3% and 5% kerosene, respectively, after a period of 16 days, at optimal growth conditions of pH 6.0, 30...

The survival of L1210 leukemic C57BL/6 X DBA2 F! mice has been studied as a function of the time interval between two i.p. doses of DNA synthesis inhibitors (1-0-D-arabinofuranosylcytosine, hydroxyurea, sodium camptothecin, and 5-hydroxy-2-formylpyridine thiosemicarbazone). In general, life-span increases that were observed with single doses of these agents (i.e., a time interval of zero) were ...

Patients treated with vaccines based on NGlycolil gangliosides have showed benefit in progression free survival and overall survival. These molecules, which have been observed in breast cancer cells, are minimally or not expressed in normal human tissue and have been considered as antigen tumor-specific. For this reason they are very attractive to immunotherapy. A phase I/II clinical trial was ...

The survival of L1210 leukemic C57BL/6 X DBA2 F! mice has been studied as a function of the time interval between two i.p. doses of DNA synthesis inhibitors (1-0-D-arabinofuranosylcytosine, hydroxyurea, sodium camptothecin, and 5-hydroxy-2-formylpyridine thiosemicarbazone). In general, life-span increases that were observed with single doses of these agents (i.e., a time interval of zero) were ...

BACKGROUND Common variable immunodeficiency disorders (CVIDs) are the most common forms of symptomatic primary antibody failure in adults and children. Replacement immunoglobulin is the standard treatment, although there are few consistent data on optimal dosages and target trough IgG levels required for infection prevention. OBJECTIVE To provide data to support the hypothesis that each patie...