Over ninety percent of End Stage Renal Disease (ESRD) patients suffer from anemia due to insufficient endogenous production of human erythropoietin. Until the advent of Recombinant Human Erythropoietin (r-HuEPO) over 30 years ago, patients with ESRD were treated mainly with multiple blood transfusions. The high cost of r-HuEPO in addition to the narrow margin between an effective dosage and tox...

Multiple model (MM) design and stochastic control of dosage regimens permits essentially full use of all the information contained in either a nonparametric EM (NPEM) population pharmacokinetic model or in an MM Bayesian updated parameter set, to achieve and maintain selected therapeutic goals with optimal precision (least predicted weighted squared error). The regimens are visibly more precise...

Objective: To study the preparation process of anti-aging healthy beverage. Methods: L9 (34) was used to identify, weigh and pretreat raw materials, optimize and make an orthogonal experiment with as reference, screen out the optimal formula of beverage blending in accordance with sensory score. Results: The best formula of anti-aging healthy beverage with compound hawthorn and Astragalus membr...

high-dose extended-interval dosage (hded) regimen of aminoglycosides is now considered as the standard dosage strategy in sepsis. although safety and efficacy of this dosing regimen is well studied, but new experiments show increased the risk of resistance development associated with %t>mic less than 60% of the dosing interval following extended interval dosing. moreover, limited information is...

This research aims to examine the efficiency of Polyaluminium Chloride (PAC) remove a reactive red 195 dye and find optimal condition coagulate this dye. In present investigation, effect pH (3-9) PAC dosages (500-5,000 mg/L) were studied 1,000 mg/L using jar test. The results showed that variations influenced PAC. With increase dosage, 500- 1,500 5,000 highest percentage colour removal in acidi...

Determining the optimal dose of coagulant required to perform flocculation is critical in most water treatment plants’ planning and operation. This study implemented a 2k–p fractional factorial design experiments identify factors influencing color decrease wastewater from slaughterhouse. The variables assessed were velocity gradient, residence time, primary dosage, chlorine coagulation adjuvant...

A mathematical model for the depletion of bone marrow under cancer chemotherapy is analyzed as an optimal control problem. The control represents the drug dosage of a single chemotherapeutic agent and pharmacokinetic equations which model its plasma concentration are included. The drug dosages enter the objective linearly. It is shown that optimal controls are bang-bang, i.e. alternate the drug...