results the most common drug used by 48 women (81.35%) was th eopium, followed by crack(8.47%), heroin (1.69%), methadone (1.69%)and cannabis (1.69%). mean age of the first time experience of cigarette smoking was 17.11 ± 9.22 years. also, the mean age of the first time drug substance use was 27.62 ± 10.46 years and the mean duration of drug use was 5.2 ± 12.0 years. among studied women, 74.57%...

abstract background and purpose: work-related musculoskeletal disorders (wmsds) are a group of painful disorders of muscles, tendons, and nerves. carpal tunnel syndrome, tendonitis, thoracic outlet syndrome, and tension neck syndrome are examples. almost all work requires the use of the arms and hands, therefore, most wmsd affect the hands, wrists, elbows, neck, and shoulders. the aim of the cu...

This article reviews neuronal activity related to reward processing in primate and human brains. In the primate brain, neurophysiological methods provide a differentiated view of reward processing in a limited number of brain structures. Dopamine neurons respond to unpredictable rewards and produce a global reinforcement signal. Some neurons in the striatum also react to the expectation and det...

Carisoprodol is a centrally acting skeletal muscle relaxant whose active metabolite is meprobamate. There have been few reports of carisoprodol abuse from India. This is a report of a case with carisoprodol dependence. The patient also had poly substance abuse of alcohol, nicotine, benzodiazepine and dextropropoxyphene. Although no specific withdrawal syndrome could be identified, the patient h...

Chronic opioid exposure induces neuroadaptative changes in several brain systems. Amongst others the alpha adrenergic system appears to be extremely sensitive to opioid exposure and has, therefore, been proposed to play a key role in opiate withdrawal symptoms. In order to better understand the influence of the noradrenergic system in opioid withdrawal and be able to develop new therapeutic str...

CONTEXT Neonatal abstinence syndrome (NAS) is a postnatal drug withdrawal syndrome primarily caused by maternal opiate use. No national estimates are available for the incidence of maternal opiate use at the time of delivery or NAS. OBJECTIVES To determine the national incidence of NAS and antepartum maternal opiate use and to characterize trends in national health care expenditures associate...

and dependence, at least in in vivo systems. The recent cloning of these receptors has enabled more penetrating Laboratory of Molecular Psychiatry Yale University School of Medicine analyses (Mansour et al., 1995), which could yet reveal alterations related to opiate addiction. For example, ex-New Haven, Connecticut 06508 posure to agonist in vitro elicits receptor desensitization and down-regu...

Chronic opiate use produces persistent changes in brain neurons that are expressed as adverse effects, including physical dependence and compulsive drug-seeking behavior. Dysregulation of the hypothalamic-pituitary-adrenal response to stress also occurs with chronic opiate administration and has been implicated as a contributing factor to continued substance abuse. This study provides the first...

This publication presents an overview of the practices and the context of pharmacotherapy of opioid dependence in selected countries of the South East Asia and Western Pacific regions of the World Health Organisation. Based on reports provided by professionals involved in treatment of opioid dependence in these regions, the document describes the current situation with opioid use and its health...