Diagnostic tests are central in the field of modern medicine. One of the main factors for interpreting a diagnostic test is the discriminatory accuracy. For a continuous-scale diagnostic test, the area under the receiver operating characteristic (ROC) curve, AUC, is a useful onenumber summary index for the diagnostic accuracy of the test. When only a particular region of the ROC curve would be ...

Developing novel nuclear cardiology approaches requires evaluating their diagnostic ability. Statistical measures such as sensitivity, specificity, receiver operating characteristic (ROC) curve, and area under the curve (AUC) are useful to evaluate the diagnostic value of novel imaging parameters. This paper reviews key statistical methods used in the evaluation of diagnostic tests and highligh...

BACKGROUND Decision curve analysis has been introduced as a method to evaluate prediction models in terms of their clinical consequences if used for a binary classification of subjects into a group who should and into a group who should not be treated. The key concept for this type of evaluation is the "net benefit", a concept borrowed from utility theory. METHODS We recall the foundations of...

Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders in pregnancy, which is associated with serious complications. In the event of early diagnosis of this disease, some of the maternal and fetal complications can be prevented. The aim of this study was to early predict gestational diabetes mellitus by two statistical models including artificial neural ne...

The area under an ROC curve (AUC) has been advocated as an evaluation criterion for bipartite ranking problems. In this paper, we study large deviation properties of the AUC; in particular, we derive a distribution-free large deviation bound for the AUC which serves to bound the expected accuracy of a ranking function in terms of its empirical AUC on an independent test sequence.1 A comparison ...

Receiver operating characteristic curve is a standard method for reporting performance of a system. In this paper we show how t o choose the optimal operating poin t when we are given a receiver operating curve, the prior probabilities, and the economic gain matrix. Unlike earlier methods, we make no assumptions regarding underlying distributions.

Background: Colorectal cancer is a common cancer and has a high rate of mortality and morbidity. This can be reduced by screening tests. Some of the studies have recently referred to Red Cell Distribution Width (RDW) as a marker for early detection of various cancers. The aim of this study was to investigate the RDW and early detection of colorectal cancer and polyp. M...

Receiver operating characteristic curve is a standard method for reporting performance of a system. In this paper we show how to choose the optimal operating point when we are given a receiver operating curve, the prior probabilities, and the economic gain matrix. Unlike earlier methods, we make no assumptions regarding underlying distributions.

OBJECTIVE The aim of this study is to assess the efficacy of cervical interleukin-6 (IL-6) compared with cervical length and its association in the prediction of preterm delivery in symptomatic women. STUDY DESIGN Observational prospective study was performed at Hospital Universitario La Fe, Valencia (Spain). SAMPLE 100 women between 24 and 34 weeks gestational age, with threatened preterm ...