background the treatment of onychomycosis is a challenge and infections are typically more severe and difficult to treat in toenails than in fingernails. objectives the current study aimed to investigate the fungicidal effect of ultraviolet radiation on the growth of dermatophytes isolated from nails. patients and methods samples from patients with clinical manifestations of onychomycosis were ...

Fusarium oxysporum has been described as a pathogen causing onychomycosis, its incidence has been increasing in immunocompetent and disseminated infection can occur in immunosuppressed individuals. We describe the first case of congenital onychomycosis in a child caused by Fusarium oxysporum. The infection being acquired in utero was proven by molecular methods with the identification of the fu...

Onychomycosis due to non-dermatophytic fungi is a well-known and increasingly common infection. For the first time ever, we report two cases of onychomycosis caused by Aspergillus persii, a recently described new Aspergillus species. After ten and three years respectively, both patients showed relapsing nail infections, and mycological tests were still positive for A. persii. In vitro antifunga...

Efinaconazole 10% topical solution is a new triazole recently approved for the treatment of onychomycosis. It inhibits fungal lanosterol 14α-demethylase in the ergosterol biosynthesis pathway, has potent antifungal activity against dermatophytes, as well as activity against Candida spp. and non-dermatophyte molds, and showed promising results in clinical trials. This review summarizes the mecha...

Onychomycosis is the most prevalent onychopathy and it requires a correct early diagnosis. Currently, the diagnostic gold standard is the association of direct mycological test with culture; however, it shows variable sensitivity. The histopathological examination of the distal nail plate, called clipping, has shown to be an adjuvant in diagnosing onychomycosis. This is an easy-to-perform, rela...

Onychomycosis is one of the most common nail disorders. Despite recent therapeutic advances with the introduction of effective systemic agents and transungual drug delivery systems, the incidence of onychomycosis is increasing. This is of concern, as the morbidity related to this infection also increases as our population ages with associated conditions, such as diabetes and immunosuppression f...

Fungal organisms could be present in the nail without any clinical manifestations. As onychomycosis in diabetics has more serious complications, early detection of such infection could be helpful to prevent them. We aim in this study to assess the possibility of detecting subclinical onychomycosis in type II diabetic patients and addressing possible associated neuropathy. A cross sectional, obs...

OBJECTIVE To assess the role of foot dermatomycosis (tinea pedis and onychomycosis) and other candidate risk factors in the development of acute bacterial cellulitis of the leg. METHODS A case-control study, including 243 patients (cases) with acute bacterial cellulitis of the leg and 467 controls, 2 per case, individually matched for gender, age (+/-5 years), hospital and admission date (+/-...

Therapeutic options for the treatment of onychomycosis range from no therapy, palliative care, mechanical or chemical debridement, topical and systemic antifungal agents to a combination of two or more of these modalities.[3] Factors that influence the choice of therapy include the presentation and severity of the disease, current medications the patient is taking, previous therapies for onycho...

In this study, nested PCR using novel primers targeting the pan-dermatophyte-specific sequence of the chitin synthase 1 gene (CHS1) was compared with KOH microscopy, culture isolation, and single-round PCR for diagnosis of 152 patients with clinically suspected onychomycosis. Results indicate that nested PCR may be considered the gold standard for the diagnosis of cases of onychomycosis for whi...