iii Populärvetenskaplig sammanfattning v Original Papers vii Introduction 1 Historical overview 1 Criteria for diagnosis of diabetes 4 Background to this thesis 5 Type 1-diabetes in childhood 5 Etiology 6 Genetic predisposition 7 Environmental risk factors 7 Type-2 diabetes in childhood 9 Diabetes related health complications 10 Renal disease in T1D patients 11 Mortality in T1D patients 13 Aim ...

BACKGROUND/AIMS The prevalence of diabetes in Korea is reported to be approximately 10%, but cases of maturity-onset diabetes of the young (MODY) are rare in Korea. A diagnostic technique for autosomal dominant MODY is being actively sought. In this regard, we used a DNA chip to investigate the frequency of mutations of the MODY3 gene (hepatocyte nuclear factor-1alpha) in Korean patients with e...

The first-line pharmacological treatment for patients with maturity-onset diabetes of the young type 1 (MODY1) and maturity-onset diabetes of the young type 3 (MODY3) are sulfonylureas (SUs) or insulin. However, several reports have suggested the possibility of using incretin-associated drugs, including dipeptidyl-peptidase-4 (DPP-4) inhibitors, for the treatment of patients with these types of...

objective: survey of the influence of hla-drb1, -dqb1 alleles, genotypes and haplotypes on age at onset of type 1 diabetes (t1d) in an iranian population materials and methods: 105 iranian t1d patients of different ethnic group and 100 ethnically, age and sex matched individuals were selected from tehran's hospitals and hla-drb, -dqb typing was performed. according to the age at onset of t1d, ...

We prove an anti-folk theorem for repeated games with private monitoring. We assume that the monitoring is su¢ ciently connected, the strategies have a …nite past (they are measurable with respect to …nite partitions of past histories), and that each period players’ preferences over actions are modi…ed by smooth idiosyncratic shocks. In all repeated game equilibria, each period play is an equil...

objective: serum leptin concentration reflects the body fat mass. there is controversial reports about the insulin effect on serum leptin concentration. we wanted to examine the effect of insulin therapy on serum leptin in children with new onset type i diabetes. materials and methods: this was a cross-sectional study in children's medical center on 34 children who had new onset type i dia...