BACKGROUND A prostacyclin analogue, ONO-1301, is reported to upregulate beneficial proteins, including stromal cell derived factor-1 (SDF-1). We hypothesized that the sustained-release delivery of ONO-1301 would enhance SDF-1 expression in the acute myocardial infarction (MI) heart and induce bone marrow cells (BMCs) to home to the myocardium, leading to improved cardiac function in mice. MET...

It has been shown previously that administration of angiogenic growth factors as genes or proteins can augment collateral growth in ischaemic tissues. In the present study, we have investigated the effect of ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase-inhibitory activity, on expression of endogenous growth factors and angiogenesis. ONO-1301 induced secretion of HGF (hep...

Isostructural vanadium, niobium and tantalum complexes of bis(3,5-di-tert-butyl-2-phenol)amine ([ONO]H3), were prepared and characterized to evaluate the impact of the metal ion on redox-activity of the ligand platform. New vanadium and niobium complexes with the general formula, [ONO]MCl2L (M = V, L = THF, 1-V; M = Nb, L = Et2O, 1-Nb) were prepared and structurally analysed by X-ray crystallog...

This paper consider the Cauchy problem for Schr$ {\rm \ddot{o}} $dinger equation coupled with stochastic Benjamin-Ono equation. A priori estimates integral and nonlinear terms corresponding to coupling system are achieved by using Fourier transform restriction method introduced Bourgain. It is shown that locally well-posed as initial data in appropriate Sobolev spaces.

The interaction of interfacial solitary waves of algebraic type is investigated on the basis of a higherorder Benjamin-Ono equation. By developing a multisoliton perturbation theory, we show analytically that the overtaking collision between two solitary waves exhibits the phase shift but the amplitudes are not altered after interaction. The predication of the phase shift that takes place betwe...

We shall deduce some special regularity properties of solutions to the IVP associated to the Benjamin-Ono equation. Mainly, for datum u0 ∈ H3/2(R) whose restriction belongs to Hm((b,∞)) for some m ∈ Z+, m≥ 2, and b ∈ R we shall prove that the restriction of the corresponding solution u(·, t) belongs to Hm((β ,∞)) for any β ∈R and any t > 0. Therefore, this type of regularity of the datum travel...

We establish an abstract infinite dimensional KAM theorem dealing with unbounded perturbation vector-field, which could be applied to a large class of Hamiltonian PDEs containing the derivative ∂x in the perturbation. Especially, in this range of application lie a class of derivative nonlinear Schrödinger equations with Dirichlet boundary conditions and perturbed Benjamin-Ono equation with peri...