DNA of human papillomavirus type 18 is present in several human cancer cell lines that were derived from oral or cervical tumors, and it is known that several features of the transformed phenotype can be inhibited by expression of antisense RNA to human papillomavirus (HPV). The present study was performed to find out whether antisense oligonucleotides were also inhibitory. Synthetic oligonucle...

Sequence anal,yses have been performed on 11 long-chainlength oligonucleotides isolated from RNase T, digests of tobacco mosaic virus ribonucleic acid. The chainlengths of these oligonucleotides range from 14-72 nucleotides. The structures of six oligonucleotides have been determined, including one that corresponds to a portion of the amino acid sequence in the coat protein. Partial sequences h...

Antisense oligonucleotides have been considered as inhibitors of growth of intracellular parasites such as Leishmania, but only limited inhibition has been observed in vitro. We have encapsulated an antisense oligonucleotide, complementary to the Leishmania universal miniexon sequence, in cationic liposomes. Low concentrations (4 microM) of encapsulated oligonucleotides specifically reduced the...