Aggregation and oligomerization have often been challenging yet exciting aspects in the study of membraneassociated proteins (1). The motivation for exploring oligomerization of membrane proteins derives from the emerging realization that oligomerization holds the key to efficient drug discovery (2). Although oligomerization is an important step for membrane proteins, dynamics play a crucial ro...

The assembly of simple transmembrane helix homo-oligomers is studied by combining a generalized Born implicit membrane model with replica exchange molecular dynamics simulations to sample the conformational space of various oligomerization states and the native oligomeric conformation. Our approach is applied to predict the structures of transmembrane helices of three proteins--glycophorin A, t...

We employ high-performance liquid chromatography with diode array, evaporative light scattering, and mass spectrometric detection to monitor the oligomerization of L-lactic acid in pure acetonitrile and in 70% aqueous ethanol. The production of higher oligomers appears to proceed in an oscillatory fashion. A model is presented that involves the formation of aggregates (micelles), which catalyze...

Abstract. The rate at which freshly formed secondary aerosol particles grow is an important factor in determining their climate impacts. growth of atmospheric nanoparticles may be affected by particle-phase oligomerization and decomposition condensing organic molecules. We used the Model for Oligomerization Decomposition Nanoparticle Growth (MODNAG) to investigate potential significance these e...

The product of the human cytomegalovirus (HCMV) UL71 gene is conserved throughout the herpesvirus family. During HCMV infection, protein pUL71 is required for efficient virion egress and is involved in the final steps of secondary envelopment leading to infectious viral particles. We found strong indications for oligomerization of pUL71 under native conditions when recombinant pUL71 was negativ...

The eukaryotic 60S-ribosomal stalk is composed of three P ribosomal proteins (P0, P1 and P2) which associate in a pentameric structure [2P1, 2P2, P0] in the ribosome. The Plasmodium falciparum protein P2 (PfP2) appears to play non-ribosomal roles. It gets exported to the infected erythrocyte (IE) surface at 30 hrs post merozoite invasion (PMI), concomitant with extensive oligomerization. Here w...

Tomato golden mosaic virus (TGMV), a member of the geminivirus family, encodes one essential replication protein, AL1, and recruits the rest of the DNA replication apparatus from its plant host. TGMV AL1 is an oligomeric protein that binds double-stranded DNA and catalyzes cleavage and ligation of single-stranded DNA. The oligomerization domain, which is required for DNA binding, maps to a regi...

This paper investigates the production of hydrocarbon resins by oligomerization in solution and suspension C9 fraction by-products from oil refining. The disadvantage existing technologies for oligomers free radical is use high reaction temperatures. application N-replaced amino peroxides as low-temperature initiators a technology can reduce temperature duration reaction. correlation between pa...