introduction : recent investigations have attempted to improve regenerative endodontics with the help of stem cell therapy. in vitro studies have shown the ability of different agents to stimulate the differentiation of dental pulp stem cells (dpsc) into odontoblast-like cells. a combination of dexamethasone, β-glycerophosphate and vitamin d has been proven to induce a successful differentiatio...

objective: evaluation of the effect of propolis as a bioactive material on quality of dentin and presence of dental pulp stem cells. materials and methods: for conducting this experimental split-mouth study,a total of 48 maxillary and mandibular incisors of male guinea pigs were randomly divided into an experimental propolis group and a control calcium hydroxide group. cutting the crowns and us...

OBJECTIVE Evaluation of the effect of Propolis as a bioactive material on quality of dentin and presence of dental pulp stem cells. MATERIALS AND METHODS For conducting this experimental split-mouth study,a total of 48 maxillary and mandibular incisors of male guinea pigs were randomly divided into an experimental Propolis group and a control calcium hydroxide group. Cutting the crowns and us...

OBJECTIVES Odontoblasts are highly differentiated post-mitotic cells, which under pathological conditions such as carious lesions and dental injuries may degenerate and be replaced by other pulp cells. We have recently shown that this physiological event can be reproduced in an in vitro assay system, but is highly modified by the presence of unpolymerized resinous monomers. Our hypothesis was t...

The penetration of cariogenic oral bacteria into enamel and dentin during the caries process triggers an immune/inflammatory response in the underlying pulp tissue, the reduction of which is considered a prerequisite to dentinogenesis-based pulp regeneration. If the role of odontoblasts in dentin formation is well known, their involvement in the antibacterial response of the dental pulp to cari...