UNLABELLED Our objective was to study the diagnostic performance of regadenoson (82)Rb myocardial perfusion PET imaging to detect obstructive coronary artery disease (CAD). METHODS We studied 134 patients (mean age, 63 ± 12 y; mean body mass index, 31 ± 9 kg/m(2)) without known CAD (96 with coronary angiography and 38 with low pretest likelihood of CAD). Stress left ventricular ejection fract...

BACKGROUND Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is not routinely measured in clinical practice. We sought to investigate the im...

PURPOSE OF REVIEW There is growing clinical interest for the use of cardiopulmonary exercise testing (CPET) to evaluate patients with or suspected coronary artery disease (CAD). With mounting evidence, this concise review with relevant teaching cases helps to illustrate how to integrate CPET data into real world patient care. RECENT FINDINGS CPET provides a novel and purely physiological basi...

OBJECTIVE We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, > or = 50% stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). METHODS AND RESULTS 191 participants (50...

CONTEXT Individual contributions of obesity and physical fitness (physical activity and functional capacity) to risk of coronary heart disease in women remain unclear. OBJECTIVE To investigate the relationships of measures of obesity (body mass index [BMI], waist circumference, waist-hip ratio, and waist-height ratio) and physical fitness (self-reported Duke Activity Status Index [DASI] and P...

BackgroundObstructive coronary artery disease (CAD) is common in patients with severe symptomatic aortic stenosis. The management and impact of obstructive CAD undergoing transcatheter valve replacement (TAVR) have not been fully evaluated. We aimed to determine the patient characteristics clinical outcomes among veterans TAVR without temporal trends association pre-TAVR percutaneous interventi...

BACKGROUND There is growing evidence about the importance of epicardial adiposity on cardiometabolic risk. However, the relation of location-specific epicardial adipose tissue (EAT) thickness to coronary atherosclerotic burden is still unclear. METHODS This meta-analysis was used to study the relations between location-specific EAT thickness and obstructive coronary artery disease (CAD). A sy...

cardiovascular disease (cad) screening in asymptomatic patients with diabetes mellitus is controversial. an exercise stress test is a safe and effective initial testing for ischemic heart disease (ihd) screening. treadmill stress test is not the best screening method for a particular patient who is not able to exercise, abnormal electrocardiogram (ecg) or positive exercise treadmill test (ett) ...

PURPOSE Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort. METHODS A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angio...

INTRODUCTION Previous studies have predicted an independent relationship between red cell distribution width (RDW) and the risk of death and cardiovascular events in patients with coronary artery disease (CAD). The aim of this study was to investigate the relationship between RDW and extensiveness of CAD in patients with diabetes mellitus (DM). METHODS Two hundred and thirty-three diabetic pa...