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KAPLAN, MURRAY L., AND GILBERT A. LEVEILLE. Core temperature, 02 consumption, and early detection of ob/ob genotype in mice. Am. J. Physiol. 227(4) : 912-915. 1974.-Oxygen consumption and core temperature of ob/ob mice and their thin littermates were measured at various ambient temperatures from 10 to 30°C. At every ambient temperature studied, adult obese mice exhibited lower 02 consumptions a...

Recent evidence has been presented that expression of lipogenic genes is downregulated in adipose tissue of ob/ob mice as well as in human obesity, suggesting a functionally lipoatrophic state. Using (2)H(2)O labeling, we measured three adipose tissue biosynthetic processes concurrently: triglyceride (TG) synthesis, palmitate de novo lipogenesis (DNL), and cell proliferation (adipogenesis). To ...

In order to examine the role of the pituitary in the obese-hyperglycemic syndrome, obese (ob/ob) and nonobese sibling (OB/?) mice were sham-operated or hypophysectomized by a parapharyngeal method at 60 to 90 days of age and subsequently weighed for nine weeks. Completeness of hypophysectomy was assessed by microscopic examination of stained serial sections of the brain and attached hypophyseal...

Patients with diabetes and obesity are at increased risk of developing disturbances in intestinal function. In this study, we characterized jejunal function in the clinically relevant leptin-deficient ob/ob mouse, a model of diabetes and obesity. We measured transepithelial short circuit current (Isc), across freshly isolated segments of jejunum from 12-week-old ob/ob and lean C57BL/6J (female ...

The development of automated methods for revealing the repetitive structure of a given music recording is of central importance in music information retrieval. In this paper, we present a novel scape plot representation that allows for visualizing repetitive structures of the entire music recording in a hierarchical, compact, and intuitive way. In a scape plot, each point corresponds to an audi...