The presence of UDP-glucuronyltransferase (EC 2.4.1.17) activity in chick-embryo liver nuclei and nuclear envelope and its inducibility by phenobarbital has been previously reported (Fry & Wishart, 1976). This enzyme has also been found in adult rat liver, with 64-76 % in the microsomal and 14-19 % in the unpuri6ed nuclear fractions (Amar-Costesec et ul., 1974). In view of the heterogeneity of ...

BACKGROUND Hair dye products constitute an important source of allergen exposure, and contribute importantly to allergic contact dermatitis in consumers and hairdressers. OBJECTIVES To evaluate the presence of potent contact sensitizers in oxidative hair dye products intended for home use on the US market. METHODS Ingredient labels of 107 hair dyes from 10 major brands were examined and use...

The ability of the liver to form glucuronides was measured in 10 patients with infectious hepatitis. One test was done at the onset and another about four weeks later after the clinical symptoms had disappeared. N-acetyl-p-aminophenol (N.A.P.A.) or acetanilide was administered in doses ranging from 10 to 20 mg. per kg. body weight, either orally or by intravenous injection. N.A.P.A. is conjugat...

A simple, rapid, and specific spectrophotometric method was developed for the determination of paracetamol in pure form drug formulations. The depended on hydrolysis to p-aminophenol, which, oxidized under effect dissolved oxygen benzoquinoneimine. In alkaline medium, benzoquinoneimine reacts with Methyldopa produce a high stabile indophenol dye. absorbance measured at 580 nm, molar absorptivit...

The generation of methaemoglobin is a rare but potential life-threatening side effect in the use of the local anaesthetic prilocaine. It is currently only possible to ensure the diagnosis by means of blood tests. Rapid noninvasive diagnosis is desirable, especially for risk patients. Using a pig model, we induced methaemoglobinemia via application of dimethyl aminophenol and prilocaine (setup I...

In view of the role ascribed to the peroxidatic activity of degradation products of cytochrome c (cyt c) in the processes of apoptosis, we investigate the catalytic potential of heme and of the cyt c derived heme peptide MP-11 to catalyse the cathodic reduction of hydrogen peroxide and to oxidize aromatic compounds. In order to check whether cyt c has an enzymatic activity in the native state w...

The reaction of o-aminophenol with para hydroxy and methoxy substituted benzaldehydes yielded two Schiff bases. These bases functioning precursors were turned into palladium complexes by treating acetate. structural formulas based on spectral methods (elemental analysis, FT-IR spectroscopy, NMR spectroscopy QTOF-LC/MS spectroscopy) suggested for obtained both complexes. According to the charact...

Four Schiff bases (H2L1 to H2L4) were synthesized by the condensation of o-aminophenol and unsaturated diketones (1,5-diarylpent-4-ene-1,3- -diones). Analytical, IR, 1H-NMR mass spectral data revealed their existence in imine?enamine form. Dibasic tetradentate coordination ML complexes (M = Cu(II), Ni(II), Co(II), Zn(II), Cd(II), Hg(II)) was established based on physical, analytical data. The f...

Two types of enantioselective [2 + 2 + 2] cycloadditions of triynes using chiral rhodium catalysts are disclosed. The intramolecular reaction of ortho-aminophenol-tethered triynes provides chiral tripodal compounds. Consecutive interand intramolecular reactions of ortho-phenylene-tethered triynes provide chiral tetraphenylenes.

The optical sensor for "tea catechins" was built by immobilizing 2,2'-(1,4-phenylenedivinylene)bis-8-hydroxyquinoline (PBHQ) on TiO₂ nanoparticles (NPs). The sensor worked by "indophenol blue" dye formation on PBHQ-immobilized TiO₂ NPs as a result of p-aminophenol (PAP) autoxidation with dissolved O₂ at pH 10. Among quercetin, rutin, naringenin, naringin, gallic acid, caffeic acid, ferulic acid...