PURPOSE Although survival with a p53 missense mutation is highly variable, p53-null mutation is an independent adverse prognostic factor for advanced stage ovarian cancer. By evaluating ovarian cancer survival based upon a structure function analysis of the p53 protein, we tested the hypothesis that not all missense mutations are equivalent. EXPERIMENTAL DESIGN The p53 gene was sequenced from...

The analysis of regression coefficients is an important issue in different scientific areas, mostly because conclusions about the relationship between variables, like causal interpretations, are drawn based on these coefficients. This paper focuses on the description of the null hypothesis of invariance of regression coefficients for multidimensional stochastic regressors. In this study, it is ...

In this paper, we prove a controllability result for a fluid-structure interaction problem. In dimension two, a rigid structure moves into an incompressible fluid governed by Navier-Stokes equations. The control acts on a fixed subset of the fluid domain. We prove that, for small initial data, this system is null controllable, that is, for a given T > 0, the system can be driven at rest and the...

In this paper, we establish a local null controllability result for a nonlinear parabolic PDE with nonlocal nonlinearities. The result relies on the (global) null controllability of similar linear equations and a fixed point argument. We also analyze other similar controllability problems and we present several open questions. © 2011 Elsevier B.V. All rights reserved.

The null exact controllability of Predator-prey model with homogeneous Neumann boundary conditions is studied.A carleman type estimate for adjoint linearized system is firstly established.Then we get the controllability of the linearized system. Finally, null exact controlla-bility for the nonlinear problem is obtained using the Kakutani's fixed point theorem.

The exact Liénard-Wiechert solutions for the point charge in arbitrary motion are shown to be null fields everywhere. These are used as a basis to introduce extended electromagnetic field equations that have null field solutions with fractional charges that combine with absolute confining potentials. ∗E-mail: [email protected] 1

background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...