Acetylenic carbanions add to nitroarenes (dinitrobenzenes, nitropyridines, etc.) to form σH-adducts that are subsequently oxidized by DDQ according to the oxidative nucleophilic substitution of hydrogen (ONSH) pathway to give nitroaryl acetylenes.

BODIPY dyes are shown to be susceptible to oxidative nucleophilic substitution of the alpha-hydrogens, incorporating nitrogen and carbon nucleophiles in a single, high yielding step. The reaction is an excellent alternative to conventional functionalization of this popular fluorophore.

The fragmentation patterns of nine di-, tri- and tetracyclic hydroquinones with potential antitumor activity were rationalized by invoking competing mechanisms that included sterically accelerated homolytic cleavage, Meerwein-type rearrangements and dehydrations through elimination or intramolecular nucleophilic substitution.

Nucleophilic substitution of 1,6,7,12-tetrachloro perylene bisimide (PBI) with n-butanethiol provided a novel, highly twisted PBI bearing four sulphur coordination sites at the bay positions, from which silver and palladium complexes were prepared.

The oxidation of Ni(II) N-confused porphyrins (NCPs) with azo radical initiators resulted in an unexpected intramolecular nucleophilic substitution reaction via a proposed Ni(III) NCP intermediate, which could be detected by HRMS.

Decakis(phenylthio)corannulene has been prepared from decachlorocorannulene by direct nucleophilic substitution; electronic structure properties and the X-ray crystal structure were determined and compared to predictions made by ab initio quantum chemical calculations.

Nucleophilic ionic sources of fluoride are essential reagents in the synthetic toolbox to access high added-value fluorinated building blocks unattainable by other means. In this review, we provide a concise description and rationale outstanding features one these reagents, tetramethylammonium (TMAF), as well disclosing different methods for its preparation, how physicochemical properties solva...

Solar photochemistry was proved to be efficient for the nucleophilic substitution of alkoxy groups by amines in alkoxynitrobenzenes. The results of the sun-induced photochemical substitution were comparable to the outcome of the same reaction under irradiation by a low-pressure mercury lamp. Using 4’-nitrobenzo-15-crown-5 as a starting material we obtained a polyether amino alcohol a precursor ...

We have synthesized the fluorine-I 8 labeled derivative of N-fert-butyl-aphenylnitrone (PBN), a free radical spin trapping agent widely used with electron spin resonance (ESR). N-tert-Butyl-a-(4-[18F]fluorophenyl)nitrone ([18F]FPBN) could be prepared with low radiochemical yield (3% decay corrected) by the direct aromatic nucleophilic substitution of N-tertbutyl-a-(4-nitrophenyl)nitrone with [1...