Milk provides a well-balanced source of amino acids and other ingredients. One of the functional ingredients in milk is lactoferrin (LF). LF presents a wide variety of bioactivities and functions as a radical scavenger in models using iron-ascorbate complexes and asbestos. Human clinical trials of oral LF administration for the prevention of colon polyps have been successful and demonstrated th...

Amylin is a peptide that aggregates into species that are toxic to pancreatic beta cells, leading to type II diabetes. This study has for the first time quantified amylin association and dissociation kinetics (association constant (ka ) = 28.7 ± 5.1 L mol-1 s-1 and dissociation constant (kd ) = 2.8 ± 0.6 ×10-4 s-1) using surface plasmon resonance (SPR). Thus far, techniques used for the sizing ...

This study is an attempt to evaluate the hepatoprotective activity of Tabernaemontana divaricata against DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant of Tabernaemontana divaricata at doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated wi...

An enrichment culture capable of naphthalene mineralization reduced Fe(III) oxides without direct contact in anaerobic soil microcosms when the Fe(III) was placed in dialysis membranes or entrapped within alginate beads. Both techniques demonstrated that a component in soil, possibly humic materials, facilitated Fe(III) reduction when direct contact between cells and Fe(III) was not possible. T...

The objective of the paper is to introduce a new model capable of modeling both Time Petri Nets (TPNs) and Networks of Timed Automata (NTA). We called it Clock Transition System (CTS). This new model incorporates the advantages of the structure of Petri nets, while introducing explicitly the concept of clocks. Transitions in the network can be guarded by an expression on the clocks and reset a ...

The hallmark of Network Text Analysis (NTA) is the creation of semantic networks or concept maps from linguistic data. Its key insight—one borrowed from studies in Social Network Analysis—is that the position of concepts within such networks reveals vital information about the meaning of the text as a whole. A second hallmark of NTA is that the structure and size of a network are independent of...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA complex and reveal evolutionary conservation of NatA biochemical properties in higher eukaryotes and uncover specific and essential functions of NatA for development, biosynthetic...

Widely used anthropogenic chelating agents EDTA and NTA are ubiquitous in wastewaters and natural waters. Chelating agents may enhance the mobility of heavy metals and radionuclides or increase eutrophication. Biodegradation of these chelates may reduce metal mobility, offering a remediation solution. Formation of metabolic intermediates was previously reported during the biodegradation of EDTA...