Cdc25 phosphatases are important in cell cycle control and activate cyclin-dependent kinases (Cdk). Efforts are currently under way to synthesize specific small-molecule Cdc25 inhibitors that might have anticancer properties. NSC 95397, a protein tyrosine phosphatase antagonist from the National Cancer Institute library, was reported to be a potent Cdc25 inhibitor. We have synthesized two hydro...

Objective: Assessment of functional recovery of neural stem cells (NSCs) and (-)-deprenyl, in a contusive spinal cord injury model in rats. Materials and Methods: A total of 24 female Sprague Dawley rats were randomly, but equally (n=6), allocated into the following groups: control, sham, NSC graft and NSC graft + (-)-deprenyl. All animals were laminectomized at the T13 level. Contusion was per...

The adult central nervous system (CNS) of the zebrafish, owing to its enrichment in constitutive neurogenic niches, is becoming an increasingly used model to address fundamental questions pertaining to adult neural stem cell (NSC) biology, adult neurogenesis and neuronal repair. Studies conducted in several CNS territories (notably the telencephalon, retina, midbrain, cerebellum and spinal cord...

Recent progress in neural stem cell- (NSC-) based tumor-targeted gene therapy showed that NSC vectors expressing an artificially engineered viral fusogenic protein, VSV-G H162R, could cause tumor cell death specifically under acidic tumor microenvironment by syncytia formation; however, the killing efficiency still had much room to improve. In the view that coexpression of another antitumoral g...

Neural stem cells (NSCs) have a high potency for differentiation to neurons and glial cells for replacement of damaged cells and paracrine effects for the regeneration and remyelination of host axons. Dental pulp is known to have a potential to differentiate into neural-like cells; therefore, dental pulp may be used as an autologous cell source for neural repair. In this study, we selectively e...

In the present work, fracture toughness (KIC) of full-depth (FD) fiber-reinforced concrete (FRC) and layered functionally graded (FGC) matrix cracked (MC) beams has been determined by equivalent relationships two-parameter model (ETPFM). Forty-eight MC-FGC MC-FD FRC beam specimens with span-depth ratios (L/d) equal 4, 5, 6 were tested under 3PB configuration. The MC length-depth ratio (ao/d) re...

The H2 molecule has two nuclear spin isomers, the so-called ortho and para isomers. Nuclear conversion (NSC) between these states is forbidden in gas phase. energy difference lowest as large 14.7 meV, corresponding to ~170 K. Therefore, each state of differently affects not only chemistry but also macroscopic dynamics space, thus, ortho-to-para abundance ratio (OPR) significant impacts on vario...

Neuroblastoma stem cells (NSCs) can cause drug resistance and tumor recurrence. This study aimed to enhance the lytic effect of dendritic cells (DCs) co-cultured with cytokine-induced killer (CIK) cells. NSCs were obtained by suspension culture, and DC-CIK cells were loaded with extracted NSC membrane-based microparticles (MMPs) before evaluating the lytic effect of DC-CIK cells on NSCs. After ...

Objective: We investigated whether neural stem cells (NSC) with transgenic expression of human nerve growth factor (hNGF) transplanted into the brain could offer a therapeutic option for the treatment of Alzheimer’s disease (AD). Methods: We infused okadaic acid into rat lateral ventricles to establish a chronic AD animal model. In addition, NSC were stably transduced with hNGF and enhanced gre...