BubR1 performs several roles during mitosis, affecting the spindle assembly checkpoint (SAC), mitotic timing, and spindle function, but the interdependence of these functions is unclear. We have analyzed in Drosophila melanogaster the mitotic phenotypes of kinase-dead (KD) BubR1 and BubR1 lacking the N-terminal KEN box. bubR1-KD individuals have a robust SAC but abnormal spindles with thin kine...

Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR), which monitors DNA integrity, and the spindle assembly checkpoint (SAC), which responds to defects in spindle attachment/tension during metaphase of mitosis and meio...

Since both sodium L-ascorbate (Na-AsA) and sodium saccharin (Na-Sac) promote two-stage bladder carcinogenesis in rats, synergism of the two chemicals was investigated with special reference to the role of urinary pH and Na+ concentration. Male F344 rats were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water for 4 wk and then treated with basal diet containing 5% Na-Sac, 5%...

أشتمل هذا البحث تحضير وتشخيص عشرة معقدات جديدة لايونات Mn (II) , Co Ni Cu Hg مع مزيج من ليكاندات السكارين والباربيتيوريك / الثايوباربيتيوريك .
 وتضمن العمل تفاعل ايونات العناصر اعلاه وحامض الباربيتيوريك او الثايو باربيتيوريك بنسبة مولية ( 1:1:1 ) فلز : سكارين حامض شخصت المعقدات المحضرة بتقنيات درجات الانصهار والحساسية المغناطيسية والتحليل الدقيق للعناصر (C.H.N.S) والتوصيلية الكهربائية المو...

The Spindle Assembly Checkpoint (SAC) delays the onset of anaphase until every chromosome is properly bioriented at the spindle equator. Mutations in SAC genes have been found in tumors and compromised SAC function can increase the incidence of some carcinomas in mice, providing further links between cancer etiology, chromosome segregation defects and aneuploidy. Here we review recent developme...

cAMP is a critical second messenger mediating activity-dependent neuronal survival and neurite growth. We investigated the expression and function of the soluble adenylyl cyclase (sAC, ADCY10) in CNS retinal ganglion cells (RGCs). We found sAC protein expressed in multiple RGC compartments including the nucleus, cytoplasm and axons. sAC activation increased cAMP above the level seen with transm...

Background: To evaluate the role of 3D, 4D and color Doppler ultrasound (US) in the assessment of early human development. Materials and Methods: 380 women with uncomplicated early pregnancy between 5 and 14 weeks were evaluated by 3D, 4D and color Doppler US. Results: Regression analysis revealed exponential rise of the gestational sac volume with gestational age throughout the first trimester...