Ausgehend von einem [(MeOC^N^C)AuCl]-Komplex als Vorstufe wurde eine direkte Substitution durch C,H-Aktivierung sp-, sp2- oder sp3-C,H-Bindungen unter basischen Bedingungen in einer Planetenkugelmühle erreicht. Aufgrund der außergewöhnlichen photophysikalischen Eigenschaften Zielverbindungen bietet dieses Verfahren einen einfachen Zugang zu wertvollen Klasse Komplexen. Im Gegensatz zuvor bereit...

S1 Compound I X-ray XYZ coordinates . . . . . . . . . . . . . . . . 4 S2 Compound II X-ray XYZ coordinates . . . . . . . . . . . . . . . 4 S3 Compound III (molecule A) X-ray XYZ coordinates . . . . . . . 4 S4 Compound III (molecule B) X-ray XYZ coordinates . . . . . . . 5 S5 Compound IV (molecule A) X-ray XYZ coordinates . . . . . . . 5 S6 Compound IV (molecule B) X-ray XYZ coordinates . . . . ...

We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = -OC(O)-p-C6H4-S-) bound to gold(I)-N-heterocyclic carbene fragments through the thiolate group: [(η5-C5H5)2TiMe(μ-mba)Au(NHC)]. The cytotoxicities of the heterometallic compounds along with those of novel monometallic gold-N-heterocyclic carbe...

Class III drugs prolong the QT interval by blocking mainly the delayed rectifier rapid potassium outward current (IKr), with little effect on depolarization. This K(+) channel in encoded by the human ether-a-go-go-related gene (hERG). Inhibition of hERG potassium currents by class III antiarrhythmic drugs causes lengthening of cardiac action potential, which produces a beneficial antiarrhythmic...

In continuation with our studies concerning the synthesis, characterization and biological evaluation of nucleolipidic Ru(III) complexes, a novel design for this family of potential anticancer agents is presented here. As a model compound, a new uridine-based nucleolipid has been prepared, named HoUrRu, following a simple and versatile synthetic procedure, and converted into a Ru(III) salt. Sta...

In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...