نتایج جستجو برای: notch depth

تعداد نتایج: 179341  

Journal: :E3S web of conferences 2021

The article deals with the vibration of subgrade soil and for sections sloping terrain location calculation methods. In calculations, we use finite element method, advantages which are simplicity obtaining systems resolving equations possibility thickening grid elements taking into account inhomogeneous deformation density properties material. stress-strain state caused by structural changes in...

Journal: :Cancer research 2014
Kelly L Weaver Marie-Clotilde Alves-Guerra Ke Jin Zhiqiang Wang Xiaoqing Han Prathibha Ranganathan Xiaoxia Zhu Thiago DaSilva Wei Liu Francesca Ratti Renee M Demarest Cristos Tzimas Meghan Rice Rodrigo Vasquez-Del Carpio Nadia Dahmane David J Robbins Anthony J Capobianco

The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and ch...

2018
Wangdi Liao Guohua Li Yu You Hongping Wan Qiong Wu Chongwen Wang Nonghua Lv

This study investigated the roles of Notch‑1 in colorectal carcinoma, to assess the mechanisms. The expression of Notch‑1 and its ligand-Jagged1 was detected in human colorectal carcinoma, colorectal adenoma, paracancerous tissue and normal colorectal tissue by immunohistochemistry. Colorectal carcinoma cell lines were utilized to confirm the expression of Notch‑1 in colorectal carcinoma cells....

Journal: :Mechanisms of Development 2001
Paul Beatus Johan Lundkvist Camilla Öberg Kia Pedersen Urban Lendahl

Notch signal transduction is mediated by proteolysis of the receptor and translocation of the intracellular domain (IC) into the nucleus, where it functions as a regulator of HES gene expression after binding to the DNA-binding protein RBP-J kappa. The mammalian Notch receptors are structurally very similar, but have distinct functions. Most notably, Notch 1 IC is a potent activator of the HES ...

2006
K. Edalati B. Panahi

In the present study, dispersion and displacement curves of ultrasonic lamb wave, propagated in Aluminum thin plates, were drawn. Two ultrasonic lamb wave techniques, pulse-echo (a1 mode as emitter) and emission (s1 mode as emitter), were used for interpretation of notch defects with depths of 10%, 30% and 60% of plate thickness. Thickness of plate was 2 mm and the nominal centre frequency of t...

Journal: :Development 1993
C A Coyle-Thompson U Banerjee

Genetic and phenotypic analysis of strawberry notch suggests that its gene product is required during embryogenesis and oogenesis, and for the development of the eye, wing and leg. Several lines of evidence suggest that strawberry notch participates together with Notch in many common pathways. A number of strawberry notch mutant phenotypes are similar to those of Notch mutants and can be rescue...

2009
Andrew K. Shepherd Ravinder Singh Cedric S. Wesley

Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity. Here we provide evidence for Notch regulation at an earlier step - mRNA 3' processing. Processing at the Notch consensus polyadenylation site appears by default to be suppressed in Drosophila embryos. Interference w...

2017
Jeremy M. Burnham Thomas Rudolf Pfeiffer Ajay C. Kanakamedala Elmar Herbst Jason Zlotnicki Amir Ata Rahnemai-Azar Marcin Kowalczuk Adam Popchak Richard Debski Volker Musahl

This open‐access article is published and distributed under the Creative Commons Attribution ‐ NonCommercial ‐ No Derivatives License (http://creativecommons.org/licenses/by‐nc‐nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article w...

Journal: :Journal of biomedical optics 2007
Yueli Chen Peter Willett Quing Zhu

Optical Doppler tomography is a valuable functional extension of optical coherence tomography (OCT) that can be used to study subsurface blood flows of biological tissues. We propose a novel frequency estimation technique that uses an adaptive notch filter (ANF) to track the depth-resolved Doppler frequency. This new technique is a minimal-parameter filter and works in the time domain without t...

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