Genetic studies in human populations and rodent models have identified regions of human chromosome 1q21-25 and rat chromosome 2 showing evidence of significant and replicated linkage to diabetes-related phenotypes. To investigate the relationship between the human and rat diabetes loci, we fine mapped the rat locus Nidd/gk2 linked to hyperinsulinemia in an F2 cross derived from the diabetic (ty...

Chromosomal substitution strains afford the opportunity to discover regions of the rat genome that contain genes related to cardiovascular traits with the long-range goal of linking these genes to physiological function. PhysGen (Programs for Genomic Applications) created a consomic panel of rats derived from the introgression of a single chromosome (> or =95% of the BN chromosome, one at a tim...

background: precarious employment is a major social determinant of health and health inequalities with effects beyond the health of workers. objective: to investigate the association between precarious employment and sickness absence in 4 nordic countries, denmark, finland, norway, and sweden. methods: logistic regression analyses were conducted separately for each country on data from 4186 res...

This study examined whether substitution of chromosome 5 containing the CYP4A genes from Brown Norway rat onto the Dahl S salt-sensitive (SS) genetic background upregulates the renal production of 20-HETE and attenuates the development of hypertension. The expression of CYP4A protein and the production of 20-HETE were significantly higher in the renal cortex and outer medulla of SS.5(BN) (chrom...

Norway rats (Rattus norvegicus) are globally distributed and concentrate in urban environments, where they live and feed in closer proximity to human populations than most other mammals. Despite the potential role of rats as reservoirs of zoonotic diseases, the microbial diversity present in urban rat populations remains unexplored. In this study, we used targeted molecular assays to detect kno...

Department of Obstetrics and Gynaecology, Akershus University Hospital, Norway, Department of Obstetrics and Gynaecology, Oestfold Hospital Trust, Norway, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway, Faculty of Medicine, University of Oslo, Norway, Specialist Virology Center, Department of Laboratory Medicine Royal Infirmary of Edinburgh of Edinburg,UK, Institu...

Martin Hagve, Petter Fosse Gjessing, Ole Martin Fuskevåg, Terje S. Larsen, and Øivind Irtun Laboratory of Surgical Research, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Cardiovascular Research Group, Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway; Department of Digestive Surgery, University Hospital of North Norway, T...

1Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. 2Innlandet Hospital Trust, Division Tynset, Tynset, Norway. 3St Olav’s University Hospital, Trondheim, Norway. 4Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway. 5The Norwegian Centre for Dementia Research, Oslo Univ...