PURPOSE Accurate prostate low dose-rate brachytherapy treatment plan evaluation is important for future care decisions. Presently, an evaluation is based on dosimetric quantifiers for the tumor and organs at risk. However, these do not account for effects of varying dose-rate, tumor repopulation and other biological effects. In this work, incorporation of the biological response is used to obta...

normal pressure hydrocephalus (nph) is characterized by gait apraxia, urinary incontinence, and dementia. mixed connective tissue disease (mctd) is an autoimmune connective tissue disease that has never been reported to cause nph. our patient was a 67-year man with a one-year history of gradual worsening gait and balance, urinary urgency with urge incontinence and decreased short-term memory. p...

PurposeNormal tissue complication probability (NTCP) models could aid the understanding of dose dependence radiation-induced toxicities after eye-preserving radiotherapy choroidal melanomas. We performed NTCP-modeling and established dose-response relationships for visual acuity (VA) deterioration common late complications treatments with proton therapy (PT).DesignRetrospective study from singl...

Background and purposeHead neck cancer (HNC) patients treated with radiotherapy often suffer from radiation-induced toxicities. Normal Tissue Complication Probability (NTCP) modeling can be used to determine the probability develop these toxicities based on patient, tumor, treatment dose characteristics. Since currently NTCP models are developed using supervised methods that discard unlabeled p...

Introduction: Planning target volume (PTV) is generated from internal treatment volume (ITV) using four-dimensional computed tomography (4D-CT) for enhanced therapeutic gain in the stereotactic body radiotherapy for lung lesions (SBRT-Lung). This study aimed to propose a strategy to generate ITV on multiple-phase 3D-CT and enhance therapeutic gain in SBRT-Lung. <stron...

Radiobiological metrics such as tumor control probability (TCP) and normal tissue complication probability (NTCP) help in assessing the quality of brachytherapy plans. Application of such metrics in clinics as well as research is still inadequate. This study presents the implementation of two indigenously designed plan evaluation modules: Brachy_TCP and Brachy_NTCP. Evaluation tools were constr...