BACKGROUND Assessment of hepatic fibrosis stage in patients with chronic hepatitis B (CHB) is indispensable for prognosis evaluation and therapeutic regime. Noninvasive tests are fast, safe and cheap and need low technical requirements for diagnosing hepatic fibrosis in CHB patients. OBJECTIVES Using the latent class model with a random-factor to estimate relative accuracy of noninvasive test...

Dry eye disease (DED) is a multifactorial that represents one of the most common ophthalmologic conditions encountered in everyday clinical practice. Traditional diagnostic tests for DED, such as subjective questionnaires, tear film break-up time and Schirmer test, are often associated with poor reproducibility reliability, which make diagnosis, follow-up, management challenging. New advances i...