PURPOSE Few published studies have simultaneously analyzed multiple prognostic factors to predict recurrence after surgery for conventional clear cell renal cortical carcinomas. We developed and performed external validation of a postoperative nomogram for this purpose. We used a prospectively updated database of more than 1,400 patients treated at a single institution. MATERIALS AND METHODS ...

BACKGROUND Improvements in the noninvasive clinical evaluation of patients at risk for bladder cancer would be of benefit both to individuals and to health care systems. We investigated the potential utility of a hybrid nomogram that combined key demographic features with the results of a multiplex urinary biomarker assay in hopes of identifying patients at risk of harboring bladder cancer. M...

Background: Although QT prolongation is associated with increased risk of torsade de pointes (TdP), the precise relationship is not well defined. Aim: To evaluate the performance of a QT nomogram in assessing the risk of TdP from QT– RR combinations. Design: Systematic review. Methods: We systematically searched MEDLINE/ EMBASE for cases of drug-induced TdP. Controls were patients taking non-ca...

BACKGROUND Patients with intermediate to advanced hepatocellular carcinoma (HCC) are most commonly treated with transarterial chemoembolization (TACE). Previous studies showed that TACE combined with recombinant human adenovirus type 5 (H101) may provide a clinical survival benefit. In the present study, we aimed to determine the survival benefit of TACE with or without H101 for patients with i...

PURPOSE To assess the efficacy of high-frequency ultrasound biomicroscopy (UBM) in improving the accuracy of phakic intraocular lens (pIOL) sizing by increasing the incidence of acceptable postoperative vault. SETTING Multiple private practices, United States. DESIGN Evaluation of diagnostic test or technology. METHODS This prospective multicenter clinical study evaluated eyes having pIOL...

Current strategy of hepatocellular carcinoma (HCC) surveillance evaluates individual risks of HCC for defining candidates for surveillance, but estimated risks are not utilized for clinical decision-making during actual screening. We sought to determine whether consideration of individual risks improve the performance of ultrasound (US)-based HCC screening in a real-world chronic hepatitis B (C...

Background/Aims Solitary hepatocellular carcinoma (HCC) is a subgroup of HCCs. We aimed to establish nomograms for predicting the survival of solitary HCC patients after hepatectomy. Methods A total of 538 solitary HCC patients were randomly classified into training and validation sets. A Cox model was used to identify predictors of overall survival (OS) in the training set. A nomogram was ge...

AIM To compare the performances of the Barcelona clinic liver cancer (BCLC) nomogram and others systems (BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma (HCC) French cohort. METHODS Data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability,...

BACKGROUND Gastrointestinal stromal tumors (GISTs) are morphologically and clinically heterogeneous tumors, and their biological behavior is difficult to predict, ranging from clinically benign to malignant. The aim of our study was to reanalyze the value of the commonly used prognostic criteria and recently reported nomogram in predicting disease recurrence in patients with primary resectable ...

OBJECTIVE To determine whether an intravenous heparin dosing nomogram based on body weight achieves therapeutic anticoagulation more rapidly than a "standard care" nomogram. DESIGN Randomized controlled trial. SETTING Two community teaching hospitals in Phoenix, Arizona, and Rochester, New York. PARTICIPANTS One hundred fifteen patients requiring intravenous heparin treatment for venous o...