abstract  introduction: hypertension is a very common cardiovascular disease with extensive effects on body organs. this study was conducted to compare the extent of target organ damage in hypertensive patients with and without significant nocturnal fall in blood pressure (dippers and non-dippers, respectively). methods: one-hundred patients with recently diagnosed hypertension underwent 24-hou...

Objective(s):Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated. Materials and Methods:We investigated the effect of FA on PC12 cells subjected to hypoxia stress, in vitro. Results:FA increased cell viability, prevented membrane damage (LDH r...

The effect of hypoxia on air-breathing onset and survival was determined in larvae of the air-breathing fishes, the three spot gourami Trichopodus trichopterus and the Siamese fighting fish Betta splendens. Larvae were exposed continuously or intermittently (12 h nightly) to an oxygen partial pressure (PO2 ) of 20, 17 and 14 kPa from 1 to 40 days post-fertilization (dpf). Survival and onset of ...

The African sharptooth catfish Clarias gariepinus has bimodal respiration, it has a suprabranchial air-breathing organ alongside substantial gills. We used automated bimodal respirometry to reveal that undisturbed juvenile catfish (N=29) breathed air continuously in normoxia, with a marked diurnal cycle. Air breathing and routine metabolic rate (RMR) increased in darkness when, in the wild, thi...

In summer, high temperatures are combined w ~ t h severe nocturnal hypoxia In the shallow water of Danish fjords. Under these conditions, the prawns Palaemonetes varians (Leach) and Palaem o n adspersus (Rathke) are spatially separated, with the former occupying the areas of highest temperature and lowest oxygen tension. If kept together, P, adspersus shows aggressive behavlour towards P varian...

Obstructive sleep apnea syndrome (OSAS) is characterized by chronic nocturnal intermittent hypoxia and sleep fragmentations. Neurocognitive dysfunction, a significant and extraordinary complication of OSAS, influences patients' career, family, and social life and reduces quality of life to some extent. Previous researches revealed that repetitive hypoxia and reoxygenation caused mitochondria an...

I have read the study by Nicholl et al 1 published in CHEST (June 2012) with a particular interest. The research ers have analyzed the home sleep monitoring data of 254 indi viduals with some degree of renal dysfunction (75 on hemodialysis). They have concluded that a decreased kidney function is associated with greater prevalence of obstructive sleep apnea (OSA) and nocturnal hypoxia. It is we...