INTRODUCTION We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. METHODS We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior test ...

the purpose of the present study was to evaluate anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations in rats. seventy male wistar rats were divided into seven equal groups and randomly assigned to receive intraperitoneal saline (s) (control group, 1.0 ml kg-1), morphine (mo) (4.0 mg kg-1), tramadol (tr) (12.5 mg kg-1), meloxicam (ml) (1.0 mg kg-1), tramadol- morphin...

Cistus ladanifer L. is a medicinal shrub traditionally used against several diseases. The present study was performed for trying to enrich the potentialities of this plant by evaluating possible analgaesic effect aqueous extract Cistus. (AECL) and oral formulation prepared from AECL. tested using acetic acid induces writhing formalin models. results showed that both herbal syrup induced signifi...

Oxysophocarpine (OSC) is an alkaloid extracted from Siphocampylus verticillatus. The aim of this study was to investigate the anti-nociceptive effects of OSC through systemic and intracerebroventricular administration in mice. Moreover, to evaluate its effectiveness and mechanism of action, this study investigated whether OSC altered the expression of γ-aminobutyric acid type A α1 (GABAAα1) rec...

As postsynaptic metabotropic subtype 1 (mGlu1) receptors are present in the thalamus, we have investigated the effect of potentiating and antagonising mGlu1 receptors on responses of thalamic neurones to noxious sensory stimulation. Extracellular recordings were made in vivo with multi-barrel iontophoretic electrodes from single neurones in the thalamus of urethane-anaesthetised rats. Responses...

Objective(s) In recent years highly selective COX-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. In this study we were looking for potent compounds with moderate selectivity for cox-2. So, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazole derivatives were synthesized and their anti-inflammatory and anti-nociceptive ac...

Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential in the development and maintenance of prolonged pain. Epigenetic mechanisms including post-translational modifications in histones are pivotal in regulating transcription. Here, we report that phosphorylation of serine 10 (S10) in histone 3 (H3) specifically occurs in a group of rat SSDHN following the activ...

Noradrenaline (NA), a key neurotransmitter of the endogenous pain inhibitory system, acutely inhibits nociceptive transmission (including that mediated by substance P), potentiates opioid analgesia, and underlies part of the antinociceptive effects of the widely prescribed tricyclic antidepressants. Lesions of noradrenergic neurons, however, result in either normal or reduced pain behavior and ...

objective(s): there are many reports about the role of rostral ventromedial medulla (rvm) in modulating stress-induced analgesia (sia). in the previous study we demonstrated that temporal inactivation of rvm by lidocaine potentiated stress-induced analgesia. in this study, we investigated the effect of permanent lesion of the rvm on sia by using formalin test as a model of acute inflammatory pa...